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Pregled bibliografske jedinice broj: 1174737

Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats


Barišić, Ivan; Balenović, Diana; Udovičić, Mario; Bardak, Darija; Strinić, Dean; Vlainić, Josipa; Vraneš, Hrvoje; Smoday, Ivan M.; Krezić, Ivan; Milavić, Marija et al.
Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats // Biomedicines, 10 (2022), 2; 265, 38 doi:10.3390/biomedicines10020265 (međunarodna recenzija, članak, znanstveni)


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Naslov
Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats

Autori
Barišić, Ivan ; Balenović, Diana ; Udovičić, Mario ; Bardak, Darija ; Strinić, Dean ; Vlainić, Josipa ; Vraneš, Hrvoje ; Smoday, Ivan M. ; Krezić, Ivan ; Milavić, Marija ; Sikirić, Sunčana ; Uzun, Sandra ; Živanović Posilović, Gordana ; Štrbe, Sanja ; Vukoja, Ivan ; Lovrić, Eva ; Lozić, Marin ; Sever, Marko ; Lovrić Benčić, Martina ; Boban Blagaić, Alenka ; Skrtić, Anita ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Biomedicines (2227-9059) 10 (2022), 2; 265, 38

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pentadecapeptide BPC 157 ; isoprenaline ; occlusion-like syndrome ; myocardial infarction ; oxidative stress ; L-NAME ; L-arginine ; rats

Sažetak
We revealed that the stable gastric pentadecapeptide BPC 157, a useful peptide therapy against isoprenaline myocardial infarction, as well as against isoprenaline myocardial reinfarction, may follow the counteraction of the recently described occlusion-like syndrome, induced peripherally and centrally, which was described for the first time in isoprenaline- treated rats. BPC 157 (10 ng/kg, 10 µg/kg i.p.), L-NAME (5 mg/kg i.p.), and L-arginine (200 mg/kg i.p.) were given alone or together at (i) 30 min before or, alternatively, (ii) at 5 min after isoprenaline (75 or 150 mg/kg s.c.). At 30 min after isoprenaline 75 mg/kg s.c., we noted an early multiorgan failure (brain, heart, lung, liver, kidney and gastrointestinal lesions), thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, in its full presentation (or attenuated by BPC 157 therapy (given at 5 min after isoprenaline) via activation of the azygos vein). Further, we studied isoprenaline (75 or 150 mg/kg s.c.) myocardial infarction (1 challenge) and reinfarction (isoprenaline at 0 h and 24 h, 2 challenges) in rats (assessed at the end of the subsequent 24 h period). BPC 157 reduced levels of all necrosis markers, CK, CK-MB, LDH, and cTnT, and attenuated gross (no visible infarcted area) and histological damage, ECG (no ST-T ischemic changes), and echocardiography (preservation of systolic left ventricular function) damage induced by isoprenaline. Its effect was associated with a significant decrease in oxidative stress parameters and likely maintained NO system function, providing that BPC 157 interacted with eNOS and COX2 gene expression in a particular way and counteracted the noxious effect of the NOS- blocker, L-NAME.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com fulir.irb.hr

Citiraj ovu publikaciju:

Barišić, Ivan; Balenović, Diana; Udovičić, Mario; Bardak, Darija; Strinić, Dean; Vlainić, Josipa; Vraneš, Hrvoje; Smoday, Ivan M.; Krezić, Ivan; Milavić, Marija et al.
Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats // Biomedicines, 10 (2022), 2; 265, 38 doi:10.3390/biomedicines10020265 (međunarodna recenzija, članak, znanstveni)
Barišić, I., Balenović, D., Udovičić, M., Bardak, D., Strinić, D., Vlainić, J., Vraneš, H., Smoday, I., Krezić, I. & Milavić, M. (2022) Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats. Biomedicines, 10 (2), 265, 38 doi:10.3390/biomedicines10020265.
@article{article, author = {Bari\v{s}i\'{c}, Ivan and Balenovi\'{c}, Diana and Udovi\v{c}i\'{c}, Mario and Bardak, Darija and Strini\'{c}, Dean and Vlaini\'{c}, Josipa and Vrane\v{s}, Hrvoje and Smoday, Ivan M. and Krezi\'{c}, Ivan and Milavi\'{c}, Marija and Sikiri\'{c}, Sun\v{c}ana and Uzun, Sandra and \v{Z}ivanovi\'{c} Posilovi\'{c}, Gordana and \v{S}trbe, Sanja and Vukoja, Ivan and Lovri\'{c}, Eva and Lozi\'{c}, Marin and Sever, Marko and Lovri\'{c} Ben\v{c}i\'{c}, Martina and Boban Blagai\'{c}, Alenka and Skrti\'{c}, Anita and Seiwerth, Sven and Sikiri\'{c}, Predrag}, year = {2022}, pages = {38}, DOI = {10.3390/biomedicines10020265}, chapter = {265}, keywords = {pentadecapeptide BPC 157, isoprenaline, occlusion-like syndrome, myocardial infarction, oxidative stress, L-NAME, L-arginine, rats}, journal = {Biomedicines}, doi = {10.3390/biomedicines10020265}, volume = {10}, number = {2}, issn = {2227-9059}, title = {Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats}, keyword = {pentadecapeptide BPC 157, isoprenaline, occlusion-like syndrome, myocardial infarction, oxidative stress, L-NAME, L-arginine, rats}, chapternumber = {265} }
@article{article, author = {Bari\v{s}i\'{c}, Ivan and Balenovi\'{c}, Diana and Udovi\v{c}i\'{c}, Mario and Bardak, Darija and Strini\'{c}, Dean and Vlaini\'{c}, Josipa and Vrane\v{s}, Hrvoje and Smoday, Ivan M. and Krezi\'{c}, Ivan and Milavi\'{c}, Marija and Sikiri\'{c}, Sun\v{c}ana and Uzun, Sandra and \v{Z}ivanovi\'{c} Posilovi\'{c}, Gordana and \v{S}trbe, Sanja and Vukoja, Ivan and Lovri\'{c}, Eva and Lozi\'{c}, Marin and Sever, Marko and Lovri\'{c} Ben\v{c}i\'{c}, Martina and Boban Blagai\'{c}, Alenka and Skrti\'{c}, Anita and Seiwerth, Sven and Sikiri\'{c}, Predrag}, year = {2022}, pages = {38}, DOI = {10.3390/biomedicines10020265}, chapter = {265}, keywords = {pentadecapeptide BPC 157, isoprenaline, occlusion-like syndrome, myocardial infarction, oxidative stress, L-NAME, L-arginine, rats}, journal = {Biomedicines}, doi = {10.3390/biomedicines10020265}, volume = {10}, number = {2}, issn = {2227-9059}, title = {Stable gastric pentadecapeptide BPC 157 may counteract myocardial infarction induced by isoprenaline in rats}, keyword = {pentadecapeptide BPC 157, isoprenaline, occlusion-like syndrome, myocardial infarction, oxidative stress, L-NAME, L-arginine, rats}, chapternumber = {265} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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