Pregled bibliografske jedinice broj: 1174357
Severe West Nile virus neuroinvasive disease: clinical characteristics, short- and long-term outcomes
Severe West Nile virus neuroinvasive disease: clinical characteristics, short- and long-term outcomes // Pathogens, 11 (2022), 1; 52, 16 doi:10.3390/pathogens11010052 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1174357 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Severe West Nile virus neuroinvasive disease: clinical characteristics, short- and long-term outcomes
Autori
Santini, Marija ; Haberle, Sara ; Židovec-Lepej, Snježana ; Savić, Vladimir ; Kusulja, Marija ; Papić, Neven ; Višković, Klaudija ; Župetić, Ivana ; Savini, Giovanni ; Barbić, Ljubo ; Tabain, Irena ; Kutleša, Marko ; Krajinović, Vladimir ; Potočnik-Hunjadi, Tanja ; Dvorski, Elizabeta ; Butigan, Tamara ; Kolaric-Sviben, Gordana ; Stevanović, Vladimir ; Gorenec, Lana ; Grgić, Ivana ; Glavač, Filip ; Mehmedović, Armin ; Listeš, Eddy ; Vilibić-Čavlek, Tatjana
Izvornik
Pathogens (2076-0817) 11
(2022), 1;
52, 16
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
West Nile virus ; encephalitis ; neuroinvasive disease ; acute flaccid paralysis ; critical care ; outcome ; modified Rankin scale ; prognosis
Sažetak
West Nile Virus Neuroinvasive Disease (WNV NID) requires prolonged intensive care treatment, resulting in high mortality and early disability. Long-term results are lacking. We have conducted an observational retrospective study with a prospective follow-up of WNV NID patients treated at the Intensive Care Unit (ICU), University Hospital for Infectious Diseases, Zagreb, Croatia, 2013–2018. Short-term outcomes were vital status, length of stay (LOS), modified Rankin Scale (mRS), and disposition at discharge. Long-term outcomes were vital status and mRS at follow-up. Twenty- three patients were identified, 78.3% males, median age 72 (range 33–84) years. Two patients (8.7%) died in the ICU, with no lethal outcomes after ICU discharge. The median ICU LOS was 19 days (range 5–73), and the median hospital LOS was 34 days (range 7–97). At discharge, 15 (65.2%) patients had moderate to severe/mRS 3–5, 6 (26.0%) had slight disability/mRS 2–1, no patients were symptom-free/mRS 0. Ten (47.6%) survivors were discharged to rehabilitation facilities. The median time to follow-up was nine months (range 6– 69). At follow-up, seven patients died (30.5%), five (21.7%) had moderate to severe/mRS 3–5, one (4.3%) had slight disability/mRS 2–1, six (26.1%) had no symptoms/mRS 0, and four (17.4%) were lost to follow-up. Briefly, ten (43.5%) survivors improved their functional status, one (4.3%) was unaltered, and one (4.3%) aggravated. In patients with severe WNV NID, intensive treatment in the acute phase followed by inpatient rehabilitation resulted in significant recovery of functional status after several months.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (CRONEUROARBO) (Vilibić Čavlek, Tatjana, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Opća bolnica Varaždin
Profili:
Ivana Grgić
(autor)
Neven Papić
(autor)
Snježana Židovec-Lepej
(autor)
Eddy Listeš
(autor)
Vladimir Krajinović
(autor)
Marko Kutleša
(autor)
Vladimir Stevanović
(autor)
Marija Kusulja
(autor)
Klaudija Višković
(autor)
Marija Santini
(autor)
Irena Tabain
(autor)
Lana Gorenec
(autor)
Tatjana Vilibić-Čavlek
(autor)
Ljubo Barbić
(autor)
Vladimir Savić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus