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Pregled bibliografske jedinice broj: 1174177

Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives


Pršir, Kristina; Horak, Ema; Kralj, Marijeta; Uzelac, Lidija; Liekens, Sandra; Murković Steinberg, Ivana; Krištafor, Svjetlana
Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives // Molecules, 27 (2022), 3; 637, 16 doi:10.3390/molecules27030637 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1174177 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives

Autori
Pršir, Kristina ; Horak, Ema ; Kralj, Marijeta ; Uzelac, Lidija ; Liekens, Sandra ; Murković Steinberg, Ivana ; Krištafor, Svjetlana

Izvornik
Molecules (1420-3049) 27 (2022), 3; 637, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
coumarin ; 1, 2, 3-triazole ; benzazole ; organic synthesis ; cytostatic evaluation ; fluorescence

Sažetak
In this work, a series of novel 1, 2, 3-triazolyl-coumarin hybrid systems were designed as potential antitumour agents. The structural modification of the coumarin ring was carried out by Cu(I)-catalysed Huisgen 1, 3-dipolar cycloaddition of 7-azido-4-methylcoumarin and terminal aromatic alkynes to obtain 1, 4-disubstituted 1, 2, 3-triazolyl-coumarin conjugates 2a–g, bis(1, 2, 3-triazolyl-coumarin)benzenes 2h–i and coumarin-1, 2, 3-triazolyl-benzazole hybrids 4a–b. The newly synthesised hybrid molecules were investigated for in vitro antitumour activity against five human cancer cell lines, colon carcinoma HCT116, breast carcinoma MCF-7, lung carcinoma H 460, human T-lymphocyte cells CEM, cervix carcinoma cells HeLa, as well as human dermal microvascular endothelial cells (HMEC-1). Most of these compounds showed moderate to pronounced cytotoxic activity, especially towards MCF-7 cell lines with IC50 = 0.3–32 μM. In addition, compounds 2a–i and 4a–b were studied by UV-Vis absorption and fluorescence spectroscopy and their basic photophysical parameters were determined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-3386 - Dizajn i sinteza novih dušikovih heterocikličkih fluorofora i fluorescentnih nanomaterijala kao kemijskih senzora za pH i metalne ione (iNFiNiTE–SENS) (Vianello, Robert, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com dx.doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Pršir, Kristina; Horak, Ema; Kralj, Marijeta; Uzelac, Lidija; Liekens, Sandra; Murković Steinberg, Ivana; Krištafor, Svjetlana
Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives // Molecules, 27 (2022), 3; 637, 16 doi:10.3390/molecules27030637 (međunarodna recenzija, članak, znanstveni)
Pršir, K., Horak, E., Kralj, M., Uzelac, L., Liekens, S., Murković Steinberg, I. & Krištafor, S. (2022) Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives. Molecules, 27 (3), 637, 16 doi:10.3390/molecules27030637.
@article{article, author = {Pr\v{s}ir, Kristina and Horak, Ema and Kralj, Marijeta and Uzelac, Lidija and Liekens, Sandra and Murkovi\'{c} Steinberg, Ivana and Kri\v{s}tafor, Svjetlana}, year = {2022}, pages = {16}, DOI = {10.3390/molecules27030637}, chapter = {637}, keywords = {coumarin, 1, 2, 3-triazole, benzazole, organic synthesis, cytostatic evaluation, fluorescence}, journal = {Molecules}, doi = {10.3390/molecules27030637}, volume = {27}, number = {3}, issn = {1420-3049}, title = {Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives}, keyword = {coumarin, 1, 2, 3-triazole, benzazole, organic synthesis, cytostatic evaluation, fluorescence}, chapternumber = {637} }
@article{article, author = {Pr\v{s}ir, Kristina and Horak, Ema and Kralj, Marijeta and Uzelac, Lidija and Liekens, Sandra and Murkovi\'{c} Steinberg, Ivana and Kri\v{s}tafor, Svjetlana}, year = {2022}, pages = {16}, DOI = {10.3390/molecules27030637}, chapter = {637}, keywords = {coumarin, 1, 2, 3-triazole, benzazole, organic synthesis, cytostatic evaluation, fluorescence}, journal = {Molecules}, doi = {10.3390/molecules27030637}, volume = {27}, number = {3}, issn = {1420-3049}, title = {Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives}, keyword = {coumarin, 1, 2, 3-triazole, benzazole, organic synthesis, cytostatic evaluation, fluorescence}, chapternumber = {637} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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  • CA Search (Chemical Abstracts)


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