Naslov
Transfusion requirements of patients after allogenic hematopoietic stem cell transplantation

Autori
Bojanić, Ines ; Golubić ćepulić, Branka ; Mazić, Sanja ; Plenković, Fini ; Ivanković, Zdravko ; Lukić, Marija ; Bogdanić, Vinko ; Sertić, Dubravka ; Mrsić, Mirando ; Serventi-Seiwerth, Ranka ; Labar, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
27th Congress of the International Society of Blood Transfusion

Mjesto i datum
Vancouver, Kanada, 24.-29.8

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
transfusion, allogenic hematopoietic stem cell transplantation

Sažetak
Allogenic hematopoietic stem cell (HSC)transplantation has become routine procedure for treatment of many hematological disease and puts great demands on blood transfusion service. We retrospectively analyzed the transfusion requirements of 232 allogenic transplant recipients treated for ALL (75 patients), AML(58), CML (46), NHL (16), AA (12), MDS (9), neuroblastoma(4), scm(2), CLL (2), MH (2), RAEB-T (2) and one for breast cancer, thalasemia beta, plasmocytoma orosteosclerosis. 219(94%) patients were transplanted with bone marrow, 9 with PBS Cand 2 with selected CD34+cells. 218 donors were related (204 brothers or sisters, II parents, 2 syngeneic twins) and 15 were unrelated. In 60, 5% transplantations patients received ABO identical, 18, 8% major incompatible, 5, 1% major/minor incompatibleand 15, 6% ADO minor incompatible grafts. According to our data, unrelated transplant recipients had significantly increased transfusion requirements than related transplant recipients (p<0, 0000 I) probably because of higher rate of transplantation related complications and mortality among them. In group of related transplant recipients, donor-recipient ABO incompatibility significantly correlated with higher transfusion requirements. The at-risk group can further be defined as major ABO-incompatible related donor recipients. Nevertheless the standard practice in our center is anti-A, anti-B and anti-AD titer monitoring and high titer antibody reducing before transplant in attempt to avoid acute hemolysis in this group of patients, they still had higher requirement for red blood cell transfusion. Since major incompatible HSC transplant recipients had also significantly (p<O, OI) longer RBC transfusion dependence, the possibility is that recipient's ABO system antibodies may not only cause incompatible red cell hemolysis but also may delay RBC engraftment.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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