Pregled bibliografske jedinice broj: 1171223
Collection and composition of autologous peripheral blood stem cells graft in patients with acute myeloid leukemia: influence on hematopoietic recovery and outcome
Collection and composition of autologous peripheral blood stem cells graft in patients with acute myeloid leukemia: influence on hematopoietic recovery and outcome // Collegium antropologicum, 34 (2010), 105-115 (podatak o recenziji nije dostupan, članak, ostalo)
CROSBI ID: 1171223 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Collection and composition of autologous
peripheral blood stem cells graft in patients with
acute myeloid leukemia: influence on hematopoietic
recovery and outcome
Autori
Raos, Mirela ; Nemet, Damir ; Bojanić, Ines ; Sertić, Dubravka ; Batiić, Drago ; Dušak, Vesna ; Dubravčić, Klara ; Mazić, Sanja ; Serventi- Seiwerth, Ranka ; Mrsić, Mirando ; Golubić- Ćepulić, Branka ; Labar, Boris
Izvornik
Collegium antropologicum (0350-6134) 34
(2010);
105-115
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo
Ključne riječi
acute myeloid leukemia, autologous peripheral blood stem cells, graft composition, stem cell transplantation
Sažetak
Hematopoietic stem cell (HSC) transplantation is a standard approach in the treatment of hematological malignant diseases. For the last 15 years the main source of cells for trasplantation have been peripheral blood stem cells (PBSC). With the availability of hematopoietic growth factors and understanding the advantages of treatment with PBSC, the application of bone marrow (BM) was supplanted. The aim of this survey was to explore the success of PBSC collection, the factors which influence the success of PBSC collection, the composition and the quality of graft and their infuence on hematopoietic recovery and outcome after transplantation in patients with acute myeloid leukemia (AML). PBSC were collected by the method of leukapheresis after applying a combination of chemotherapy and growth factors or only growth factors. The quality of graft was determined with the clonogenic progenitor cell assay and with the flow citometry analysis. Of the total 134 patients with AML, who were submitted to HSC mobilization, the collection was successful in 78 (58.2%) patients. The collection was more successful after the first than after the second attempt of HSC mobilization (49% vs. 11%). The criteria for effective mobilization were the number of leukocytes >3 ´109/L and the concentration of CD34+ cells >20´103/mL in the peripheral blood on the first day of leukapheresis. The number of CD34+ cells infused had the strongest impact on hematopoietic recovery. We noted significantly faster hematological recovery of neutrophils and platelets, fewer number of transfused units of red blood cells and platelets, shorter duration of the tranfusion support, shorter treatment with intravenous antibiotic therapy and shorter hospitalization after PBSC compared to BM transplantation. These advantages could provide their standard application in the treatment of patients with AML.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Fakultet organizacije i informatike, Varaždin,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
KLARA DUBRAVČIĆ
(autor)
Branka Golubić Ćepulić
(autor)
Mirando Mrsić
(autor)
Vesna Dušak
(autor)
Dubravka Sertić
(autor)
Mirela Raos
(autor)
Sanja Mazić
(autor)
Boris Labar
(autor)
Ranka Serventi-Seiwerth
(autor)
Ines Bojanić
(autor)
Damir Nemet
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE