Naslov
Dyslipidemia: Current Perspectives and Implications for Clinical Practice

Autori
Klobučar Majanović, Sanja ; Cvijanović Peloza, Olga ; Detel, Dijana ; Kenđel Jovanović, Gordana ; Bakula Miro ; Rahelić, Dario ; Čaljkušić Mance, Tea ; Šoić Vranić, Tamara ; Zoričić Cvek, Sanja ; Bakula, Miro ; Rahelic, Dario

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Management of Dyslipidemia

Urednik/ci
Wilbert S, Aronow

Izdavač
IntechOpen

Grad
Rijeka

Godina
2021

Raspon stranica
148-158

ISBN
978-1-83968-508-8

Ključne riječi
atherosclerosis ; dyslipidemia ; cardiovascular disease ; lipid-lowering therapies ; lipoproteins

Sažetak
Dyslipidemia refers to a broad spectrum of various genetic and acquired disorders that affect blood lipid levels and largely contribute to global cardiovascular disease burden. Consistent evidence from epidemiological and clinical studies, supports the key role of the circulating LDL- cholesterol and other apoB containing lipoproteins in atherogenesis. All ApoB-containing lipoproteins with size less than 70 nm can cross the endothelial barrier, particularly in the presence of endothelial dysfunction. Uptake and accumulation of apoB-containing lipoproteins in the arterial wall is a critical initiating event in the development of atherosclerosis. Statin treatment, targeting LDL cholesterol reduction, remains the cornerstone of dyslipidemia management. There are abundant data supporting the concept of ‘the lower LDL-C, the better’ in the primary and secondary cardiovascular disease prevention. This chapter provides an overview of the key insights into the lipid abnormalities associated with an increased risk of CV events particulary in the context of dyslipidemia management in everyday clinical practice. Understanding the important role that metabolic derangements play in the pathogenesis of atherosclerosis pave the way for stronger implementation of current guidelines for CVD risk assessment and prevention.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA