Pregled bibliografske jedinice broj: 1168929
Wnt Signaling Pathway Is among the Drivers of Liver Metastasis
Wnt Signaling Pathway Is among the Drivers of Liver Metastasis // Livers, 1 (2021), 4; 180-200 doi:10.3390/livers1040015 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1168929 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Wnt Signaling Pathway Is among the Drivers of Liver
Metastasis
Autori
Samaržija, Ivana
Izvornik
Livers (2673-4389) 1
(2021), 4;
180-200
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
Wnt signaling pathway ; liver metastasis ; hepatocellular carcinoma ; colorectal cancer ; breast cancer ; gastric cancer ; lung cancer ; melanoma ; pancreatic cancer ; prostate cancer
Sažetak
Liver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. Its role in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, metastasis formation, and other steps of the metastatic cascade are presented. Additionally, the roles of the Wnt signaling pathway in the liver metastasis formation of colorectal, breast, gastric, lung, melanoma, pancreatic, and prostate cancer are explored. The special emphasis is given to the role of the Wnt signaling pathway in the communication between the many of the components of the primary and secondary cancer microenvironment that contribute to the metastatic outgrowth in the liver. The data presented herein are a review of the most recent publications and advances in the field that add to the idea that the Wnt pathway is among the drivers of liver metastasis and that its targeting could potentially relieve liver metastasis–related complications.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
