Pregled bibliografske jedinice broj: 1167076
Difference of Symptoms Networks in Early and Late Phase Schizophrenia; A Cross-Sectional Network Analysis
Difference of Symptoms Networks in Early and Late Phase Schizophrenia; A Cross-Sectional Network Analysis // Psychiatria Danubina, 33 (2021), 710-718 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1167076 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Difference of Symptoms Networks in Early and Late
Phase Schizophrenia; A Cross-Sectional Network
Analysis
Autori
Đuran, Nataša ; Sušac, Jelena ; Vidović, Domagoj ; Bošnjak, Dina ; Vukojević, Jakša ; Bajić, Žarko ; Henigsberg, Neven ; Jukić, Vlado
Izvornik
Psychiatria Danubina (0353-5053) 33
(2021);
710-718
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
schizophrenia ; psychosis ; PANSS ; networks ; symptoms
Sažetak
Objective: The functional remission or recovery of schizophrenia patients is a challenging task which relies on pharmacotherapy but also on the timing of psychotherapy and other therapeutic interventions. The study aimed to assess the difference in strength and structure of symptoms networks between early and late phase schizophrenia. Our secondary objective was to check whether the overall, positive, negative, and general symptoms severity change over the course of treatment and disorder. Methods: This nested cross-sectional analysis combined the samples from two studies performed during 2014-2016 at University Psychiatric Hospital Vrapče, Zagreb, Croatia on the consecutive sample of men 30-60 years old diagnosed with schizophrenia, 85 of them in the early (≤5 years from diagnosis), and 143 in the late phase of the illness. The study was funded by the project: "Biomarkers in schizophrenia - integration of complementary methods in longitudinal follow up of FEP patients". Results: Median (IQR) age of the participant in the early phase was 36 (32-45) years and in the late phase 44 (38-49) years. Patients in the early phase had significantly higher odds for being in the symptomatic remission compared to the patients in the latephase schizophrenia (OR=2.11 ; 95% CI 1.09-4.09) and had 10% less pronounced negative symptoms. The global strength, density, and structure of the symptoms network were not significantly different between the two study groups. Conclusions: Negative symptoms severity change with the course of illness and differ from the early to the late phase of schizophrenia. However, the overall network of psychotic symptoms is relatively stable, and overall strengths or density and the partial relationship between particular symptoms do not change significantly. The observed worsening of negative symptoms is probably at least partially caused by the lack of clear guidelines and effective treatment options aimed specifically toward negative symptoms.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Psihijatrijska bolnica "Sveti Ivan" Zagreb
Profili:
Domagoj Vidović
(autor)
Jelena Sušac
(autor)
Neven Henigsberg
(autor)
Jakša Vukojević
(autor)
Vlado Jukić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE