Pregled bibliografske jedinice broj: 1166388
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection? // Physiological research, 70 (2021), Suppl. 2; S249-S252 doi:10.33549/physiolres.934725 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 1166388 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?
Autori
Starčević Čizmarević, Nada ; Kapović, Miljenko ; Rončević, Dobrica ; Ristić, Smiljana
Izvornik
Physiological research (0862-8408) 70
(2021), Suppl. 2;
S249-S252
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
CCR5-Δ32 ; CCR5 ; COVID-19 ; SARS-CoV-2
Sažetak
Increasing evidence points to host genetics as a factor in COVID-19 prevalence and outcome. CCR5 is a receptor for proinflammatory chemokines that are involved in host responses, especially to viruses. The CCR5 Δ32 minor allele is an interesting variant, given the role of CCR5 in some viral infections, particularly HIV-1. Recent studies of the impact of CCR5-Δ32 on COVID-19 risk and severity have yielded contradictory results. This ecologic study shows that the CCR5-Δ32 allelic frequency in a European population was significantly negatively correlated with the number of COVID-19 cases (p=0.035) and deaths (p=0.006) during the second pandemic wave. These results suggest that CCR5-Δ32 may be protective against SARS-CoV-2 infection, as it is against HIV infection, and could be predictive of COVID-19 risk and severity. Further studies based on samples from populations of different genetic backgrounds are needed to validate these statistically obtained findings.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
MEDRI--uniri-biomed-18-137 - Farmakogenetika multiple skleroze: odgovor na imunomodulacijsku terapiju (Starčević Čizmarević, Nada, MEDRI ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)