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Pregled bibliografske jedinice broj: 1165188

The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls


Pivac, Nela; Nedić Erjavec, Gordana; Šagud, Marina; Nikolac Perković, Matea; Tudor, Lucija; Uzun, Suzana; Kovačić Petrović, Zrnka; Konjevod, Marcela; Dvojković, Anja; Kozumplik, Oliver et al.
The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls // Progress in neuro-psychopharmacology & biological psychiatry, 113 (2022), 110452, 10 doi:10.1016/j.pnpbp.2021.110452 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1165188 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls

Autori
Pivac, Nela ; Nedić Erjavec, Gordana ; Šagud, Marina ; Nikolac Perković, Matea ; Tudor, Lucija ; Uzun, Suzana ; Kovačić Petrović, Zrnka ; Konjevod, Marcela ; Dvojković, Anja ; Kozumplik, Oliver ; Svob Strac, Dubravka ; Peraica, Tina ; Mimica, Ninoslav ; Živković, Maja ; Hirasawa-Fujita, Mika ; Domino, Edward F.

Izvornik
Progress in neuro-psychopharmacology & biological psychiatry (0278-5846) 113 (2022); 110452, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BDNF genetic variants ; Smoking ; Schizophrenia ; PTSD ; Alcohol dependence ; Depression ; Healthy subjects

Sažetak
Studies investigating the association between smoking and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have reported inconclusive results, while the studies on the association of smoking status with BDNF C270T polymorphism are missing. We aimed to determine the association of smoking and BDNF Val66Met and C270T genetic variants in control subjects and patients with mental disorders. This study included 3502 Caucasian subjects: 918 healthy controls and 2584 patients with mental disorders (519 individuals with posttraumatic stress disorder (PTSD), 419 patients with depression, 996 patients with schizophrenia, and 650 patients with alcohol dependence). The frequency of the BDNF Val66Met and C270T variants were presented in codominant, dominant and recessive models. BDNF C270T, but not BDNF Val66Met polymorphism, was significantly associated with smoking in all groups, since the presence of the C270T T allele was more frequently found in smokers compared to non-smokers. Significant predictors of smoking were sex, age and BDNF C270T genetic variants. However, after detailed analysis of the separate diagnostic entities, the significant association of BDNF C270T polymorphism was confirmed only in healthy subjects, but not in patients with mental disorders ; and was not related to number of cigarettes smoked per day. In patients with alcohol dependence, the severity of smoking was significantly associated with BDNF Val66Met variants. This is a first report of the significant association between the BDNF C270T polymorphism and smoking status in the large groups of Caucasian cases/controls.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Pivac, Nela; Nedić Erjavec, Gordana; Šagud, Marina; Nikolac Perković, Matea; Tudor, Lucija; Uzun, Suzana; Kovačić Petrović, Zrnka; Konjevod, Marcela; Dvojković, Anja; Kozumplik, Oliver et al.
The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls // Progress in neuro-psychopharmacology & biological psychiatry, 113 (2022), 110452, 10 doi:10.1016/j.pnpbp.2021.110452 (međunarodna recenzija, članak, znanstveni)
Pivac, N., Nedić Erjavec, G., Šagud, M., Nikolac Perković, M., Tudor, L., Uzun, S., Kovačić Petrović, Z., Konjevod, M., Dvojković, A. & Kozumplik, O. (2022) The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls. Progress in neuro-psychopharmacology & biological psychiatry, 113, 110452, 10 doi:10.1016/j.pnpbp.2021.110452.
@article{article, author = {Pivac, Nela and Nedi\'{c} Erjavec, Gordana and \v{S}agud, Marina and Nikolac Perkovi\'{c}, Matea and Tudor, Lucija and Uzun, Suzana and Kova\v{c}i\'{c} Petrovi\'{c}, Zrnka and Konjevod, Marcela and Dvojkovi\'{c}, Anja and Kozumplik, Oliver and Svob Strac, Dubravka and Peraica, Tina and Mimica, Ninoslav and \v{Z}ivkovi\'{c}, Maja and Hirasawa-Fujita, Mika and Domino, Edward F.}, year = {2022}, pages = {10}, DOI = {10.1016/j.pnpbp.2021.110452}, chapter = {110452}, keywords = {BDNF genetic variants, Smoking, Schizophrenia, PTSD, Alcohol dependence, Depression, Healthy subjects}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2021.110452}, volume = {113}, issn = {0278-5846}, title = {The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls}, keyword = {BDNF genetic variants, Smoking, Schizophrenia, PTSD, Alcohol dependence, Depression, Healthy subjects}, chapternumber = {110452} }
@article{article, author = {Pivac, Nela and Nedi\'{c} Erjavec, Gordana and \v{S}agud, Marina and Nikolac Perkovi\'{c}, Matea and Tudor, Lucija and Uzun, Suzana and Kova\v{c}i\'{c} Petrovi\'{c}, Zrnka and Konjevod, Marcela and Dvojkovi\'{c}, Anja and Kozumplik, Oliver and Svob Strac, Dubravka and Peraica, Tina and Mimica, Ninoslav and \v{Z}ivkovi\'{c}, Maja and Hirasawa-Fujita, Mika and Domino, Edward F.}, year = {2022}, pages = {10}, DOI = {10.1016/j.pnpbp.2021.110452}, chapter = {110452}, keywords = {BDNF genetic variants, Smoking, Schizophrenia, PTSD, Alcohol dependence, Depression, Healthy subjects}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2021.110452}, volume = {113}, issn = {0278-5846}, title = {The association between BDNF C270T genetic variants and smoking in patients with mental disorders and in healthy controls}, keyword = {BDNF genetic variants, Smoking, Schizophrenia, PTSD, Alcohol dependence, Depression, Healthy subjects}, chapternumber = {110452} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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