Naslov
Triazolylpyrene-derived Pseudopeptides: Fluorescence Properties, Cell-imaging and Antiproliferative Activity

Autori
Belovari, Mateja ; Nestić, Davor ; Majhen, Dragomira ; Džolić, Zoran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27HSKIKI : book of abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pyrene ; self-aggregation ; cell-imaging ; antiproliferative activity

Sažetak
Polyaromatic chromophores are one of the most studied groups of the chemosensor molecules due to the their fluorescence properties. Pyrene is one of the most useful fluorogenic units due to its high detection sensitivity and its ability to form an excimer. Changes to the intensity of fluorescence emission confirm the formation of self assembled complex. Due to their many interesting fluorescence properties, pyrene and its derivatives are of considerable interest for the development of sensors and diagnostic tools. A series of mono- (2a-c) and bis-1, 2, 3- triazolepyrene-appended (1a-c) retropeptides were designed and prepared in excellent yields via the standard copper-catalysed azide-alkyne cycloaddition (CuAAC). Their photophysical properties and morphology were fully investigated by UV–visible and fluorescence spectroscopy as well as AFM. The bis-1, 2, 3-triazole (1a-c) derivatives were prone to self-assemble into fluorescent nanoparticles in aqueous media. In vitro antiproliferative activities of the novel 1, 2, 3-triazoles were evaluated against two human cancer cell lines, including A549 and RD cell lines, via the MTT assay. The novel mono- (2a-c) and bis-1, 2, 3-triazoles (1a-c) developed in this work can ideally be utilised as potent candidates for pharmaceutical applications.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA