Pregled bibliografske jedinice broj: 1163186
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cancer cells to cisplatin cytotoxicity
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cancer cells to cisplatin cytotoxicity // Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“
Rijeka, Hrvatska, 2019. str. /-/ (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1163186 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Oleanolic acid attenuates cisplatin-induced
nephrotoxicity in mice and chemosensitizes human
cancer cells to cisplatin cytotoxicity
Autori
Potočnjak, Iva ; Šimić, Lidija ; Vukelić, Iva ; Domitrović, Robert
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“
/ - , 2019, /-/
Skup
Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“
Mjesto i datum
Rijeka, Hrvatska, 19.09.2019. - 20.09.2019
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
oleanolic acid ; colon cancer ; apoptosis ; autophagy ; mitophagy, 5-fluorouracil
Sažetak
Oleanolic acid (OA) is a natural triterpenoid that possesses beneficial health effects such as antioxidant, anti-inflammatory, and anti-apoptotic activities. We investigated the therapeutic effect of OA (10 and 40 mg/kg) on cisplatin (CP)-induced (13 mg/kg) nephrotoxicity. Treatment with OA 40 mg/kg once daily for 2 days, 48 h after CP- intoxication, ameliorated the increased serum markers and histological features of kidney injury. Also, CP administration increased renal expression of HO-1 and 4-HNE as well as the expression of TNF-α and NF-κB, which was reduced by OA, indicating the inhibition of oxidative stress and inflammation. Increased expression of caspase-3/9 with a concomitant increase in PARP cleavage, which suggested CP-induced apoptosis in the kidneys, was inhibited by OA. Treatment with OA also ameliorated LC3B-II and Atg5 expression induced by CP, indicating the anti-autophagic activity of OA in the kidneys. Interestingly, OA increased CP cytotoxicity in HeLa cancer cells by inducing autophagic cell death. The chemosensitization of HeLa cells to CP suggests an additional beneficial effect of OA in cervical cancer patients due to reduced CP dosage requirements.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
MEDRI--uniri-biomed-18-30 - Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta (Domitrović, Robert, MEDRI ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
