Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson’s disease

Kalčec, Nikolina; Peranić, Nikolina; Barbir, Rinea; Hall, Christopher R.; Smith, Trevor A.; Sani, Marc Antoine; Frkanec, Ruža; Separovic, Frances; Vinković Vrček, Ivana

doi:10.1016/j.saa.2021.120707

Pregled bibliografske jedinice broj: 1162975

Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson’s disease

Kalčec, Nikolina; Peranić, Nikolina; Barbir, Rinea; Hall, Christopher R.; Smith, Trevor A.; Sani, Marc Antoine; Frkanec, Ruža; Separovic, Frances; Vinković Vrček, Ivana

Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson’s disease // Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 268 (2022), 120707, 13 doi:10.1016/j.saa.2021.120707 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1162975 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson’s disease

Autori
Kalčec, Nikolina ; Peranić, Nikolina ; Barbir, Rinea ; Hall, Christopher R. ; Smith, Trevor A. ; Sani, Marc Antoine ; Frkanec, Ruža ; Separovic, Frances ; Vinković Vrček, Ivana

Izvornik
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (1386-1425) 268 (2022); 120707, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nanodelivery system ; binding affinity ; fluorescence quenching ; drug loading efficiency ; nanoparticles

Sažetak
Nano-drug delivery systems may potentially overcome current challenges in the treatment of Parkinson's disease (PD) by enabling targeted delivery and more efficient blood-brain penetration ability. This study investigates novel gold nanoparticles (AuNPs) to be used as delivery systems for L-DOPA and dopamine by considering their binding capabilities in the presence and absence of a model protein, bovine serum albumin (BSA). Four different AuNPs were prepared by surface functionalization with polyethylene glycol (PEG), 1-adamantylamine (Ad), 1-adamantylglycine (AdGly), and peptidoglycan monomer (PGM). Fluorescence and UV-Vis measurements demonstrated the strongest binding affinity and L-DOPA/dopamine loading efficiency for PGM-functionalized AuNPs with negligible impact of the serum protein presence. Thermodynamic analysis revealed a spontaneous binding process between L-DOPA or dopamine and AuNPs that predominantly occurred through van der Waals interactions/hydrogen bonds or electrostatic interactions. These results represent PGM-functionalized AuNPs as the most efficient at L-DOPA and dopamine binding with a potential to become a drug-delivery system for neurodegenerative diseases. Detailed investigation of L-DOPA/dopamine interactions with different AuNPs was described here for the first time. Moreover, this study highlights a cost- and time-effective methodology for evaluating drug binding to nanomaterials.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Kemijsko inženjerstvo, Farmacija

POVEZANOST RADA

Projekti:
HRZZ-PZS-2019-02-4323 - Siguran pristup za razvoj nano-sustava za ciljanu isporuku lijekova u mozak (SENDER) (Vinković Vrček, Ivana, HRZZ ) ( CroRIS)
HRZZ-IP-2018-01-6910 - Sinteza supramolekulskih samo-udruženih nanostruktura za izgradnju naprednih funkcionalnih materijala (SUPeRNANO) (Frkanec, Leo, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Sveučilište u Zagrebu

Profili:

Nikolina Kalčec (autor)