Naslov
Drug-induced Fatty Liver Disease: Pathogenesis and Treatment

Autori
Omanovic Kolaric, Tea ; Nincevic, Vjera ; Kuna, Lucija ; Duspara, Kristina ; Bojanic, Kristina ; Vukadin, Sonja ; Raguz-Lucic, Nikola ; Wu, George Y ; Smolic, Martina

Izvornik
Journal of clinical and translational hepatology (2225-0719) 9 (2021), 5; 731-737

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Metabolic dysfunction-associated fatty liver disease, Drug-induced liver injury, Reactive oxygen species, Free fatty acids, Pharmacogenetics

Sažetak
Metabolic dysfunction-associated fatty liver disease (commonly known as MAFLD) impacts global health in epidemic proportions, and the resulting morbidity, mortality and economic burden is enormous. While much attention has been given to metabolic syndrome and obesity as offending factors, a growing incidence of polypharmacy, especially in the elderly, has greatly increased the risk of drug-induced liver injury (DILI) in general, and drug-induced fatty liver disease (DIFLD) in particular. This review focuses on the contribution of DIFLD to DILI in terms of epidemiology, pathophysiology, the most common drugs associated with DIFLD, and treatment strategies.

Izvorni jezik
Engleski

POVEZANOST RADA