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Pregled bibliografske jedinice broj: 1162777

The role of uroguanylin in ischemic stroke


Ratko, Martina; Habek, Nikola; Dobrivojević Radmilović, Marina; Škokić, Siniša; Justić, Helena; Barić, Anja; Dugandžić, Aleksandra
The role of uroguanylin in ischemic stroke // 12th FENS Forum of Neuroscience
Virtualni kongres (Glasgow, Ujedinjeno Kraljevstvo), 2020. 3767, 1 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1162777 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The role of uroguanylin in ischemic stroke

Autori
Ratko, Martina ; Habek, Nikola ; Dobrivojević Radmilović, Marina ; Škokić, Siniša ; Justić, Helena ; Barić, Anja ; Dugandžić, Aleksandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
12th FENS Forum of Neuroscience

Mjesto i datum
Virtualni kongres (Glasgow, Ujedinjeno Kraljevstvo), 11.07.2020. - 15.07.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
guanylate cyclase-C ; middle cerebral artery occlusion ; MR imaging ; Ca2+ signaling

Sažetak
AIM: Recent research has shown that the activation of guanylate cyclase (GC)-A leads to a decrease of brain lesion size following middle cerebral artery occlusion (MCAO). Our aim was to investigate the potential role of uroguanylin (UGN)-dependent signalling pathways in the development of ischemic stroke. METHODS: Lesion volumes were measured in WT, GC-C and UGN-KO mice by MR imaging 1 and 7 days after MCAO. Intracellular Ca2+ concentrations were measured in slices of ipsilateral and contralateral hemispheres. RESULTS: GC-C-KO animals exhibited significantly smaller lesion volumes 1 day after MCAO than WT mice, with no difference 7 days later. This difference was not present between UGN-KO and WT littermates, although there was significant difference in UGN- dependent activation of Ca2+ signalling pathway in penumbral zone of ischemic lesion. CONCLUSION: The reduction in stroke volume present in GC-C-KO but not UGN-KO mice indicates that the activation of GC-C may cause an increase in ischemic lesion volumes, while GC-C-independent (Ca2+-dependent) signalling pathway may have protective effect. ACKNOWLEDGEMENTS Research was funded by the Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience (project “Experimental and clinical research of hypoxic- ischemic damage in perinatal and adult brain” ; GA KK01.1.1.01.0007 funded by the European Union through the European Regional Development Fund). The work of doctoral student Anja Barić has been fully supported by the “Young researchers' career development project – training of doctoral students” and project BRADISCHEMIA (UIP-2017-05- 8082) of the Croatian Science Foundation funded by the European Union from the European Social Fund.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
--KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (ZCI Neuro) (Judaš, Miloš) ( CroRIS)
--UIP-2017-05-8082 - Uloga bradikinina u ishemiji mozga i mrežnice u mišjim modelima dijabetesa (BRADISCHEMIA) (Radmilović Dobrivojević, Marina) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Ratko, Martina; Habek, Nikola; Dobrivojević Radmilović, Marina; Škokić, Siniša; Justić, Helena; Barić, Anja; Dugandžić, Aleksandra
The role of uroguanylin in ischemic stroke // 12th FENS Forum of Neuroscience
Virtualni kongres (Glasgow, Ujedinjeno Kraljevstvo), 2020. 3767, 1 (poster, međunarodna recenzija, sažetak, znanstveni)
Ratko, M., Habek, N., Dobrivojević Radmilović, M., Škokić, S., Justić, H., Barić, A. & Dugandžić, A. (2020) The role of uroguanylin in ischemic stroke. U: 12th FENS Forum of Neuroscience.
@article{article, author = {Ratko, Martina and Habek, Nikola and Dobrivojevi\'{c} Radmilovi\'{c}, Marina and \v{S}koki\'{c}, Sini\v{s}a and Justi\'{c}, Helena and Bari\'{c}, Anja and Dugand\v{z}i\'{c}, Aleksandra}, year = {2020}, pages = {1}, chapter = {3767}, keywords = {guanylate cyclase-C, middle cerebral artery occlusion, MR imaging, Ca2+ signaling}, title = {The role of uroguanylin in ischemic stroke}, keyword = {guanylate cyclase-C, middle cerebral artery occlusion, MR imaging, Ca2+ signaling}, publisherplace = {Virtualni kongres (Glasgow, Ujedinjeno Kraljevstvo)}, chapternumber = {3767} }
@article{article, author = {Ratko, Martina and Habek, Nikola and Dobrivojevi\'{c} Radmilovi\'{c}, Marina and \v{S}koki\'{c}, Sini\v{s}a and Justi\'{c}, Helena and Bari\'{c}, Anja and Dugand\v{z}i\'{c}, Aleksandra}, year = {2020}, pages = {1}, chapter = {3767}, keywords = {guanylate cyclase-C, middle cerebral artery occlusion, MR imaging, Ca2+ signaling}, title = {The role of uroguanylin in ischemic stroke}, keyword = {guanylate cyclase-C, middle cerebral artery occlusion, MR imaging, Ca2+ signaling}, publisherplace = {Virtualni kongres (Glasgow, Ujedinjeno Kraljevstvo)}, chapternumber = {3767} }




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