Pregled bibliografske jedinice broj: 1161846
Untargeted metabolomic profiling of plasma from dogs with idiopathic dilated cardiomyopathy
Untargeted metabolomic profiling of plasma from dogs with idiopathic dilated cardiomyopathy // 45TH WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS
Varšava, Poljska; online, 2021. str. 90-90 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1161846 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Untargeted metabolomic profiling of plasma from dogs
with idiopathic dilated cardiomyopathy
Autori
Rubić, Ivana ; Horvatić, Anita ; Kovačević, Alan ; Barić Rafaj, Renata ; Bilić, Petra ; Jović, Ines ; Kuleš, Josipa ; Mrljak, Vladimir
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
45TH WORLD SMALL ANIMAL VETERINARY ASSOCIATION CONGRESS
Mjesto i datum
Varšava, Poljska; online, 21.03.2021. - 24.03.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Idiopathic dilated cardiomyopathy ; plasma samples ; metabolomics
Sažetak
Idiopathic dilated cardiomyopathy (iDCM) is the second most common cardiac disease in dogs, and the major cause of morbidity and mortality in various dog breeds. It is characterized by dilatation and impaired contraction of the left or both ventricles and carries a poor prognosis with progression to congestive heart failure or fatal arrhythmias.Plasma was collected from 8 dogs with iDCM and 12 healthy dogs. The plasma metabolome was analysed using untargeted metabolomics approach by applying UHPLC and Q Exactive Plus Orbitrap Mass Spectrometer operating in alternating positive and negative modes with mass resolution 70.000 at m/z range 70-1050. Analyses were performed using Polyomics integrated Metabolomics Pipeline (PiMP) program specifically designed for metabolomics.Metabolomics analysis resulted in the annotation of 2636 peaks, 237 of which showed statistically significant differences (p<0.05) between dogs with iDCM and healthy control. Among them, 48 metabolites were identified using standards. When the two groups were compared, the most significant metabolites are O-Acetylcarnitine, L-Carnitine and cis- Aconitic acid.The study shows that the differences in plasma metabolome between dogs with iDCM and healthy dogs can be detected with an untargeted metabolomics approach using UHPLC-MS/MS method. O- Acetylcarnitine, L-Carnitine, and cis-Aconitic acid may have potential in the discovery of biomarkers relevant for iDCM.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Veterinarska medicina
POVEZANOST RADA
Projekti:
IP-2018-01-8324 - Metabolomski pristupi u otkrivanju novih biomarkera i dubinska fenotipizacija u bolestima bubrega i srca pasa (MetaDog) (Mrljak, Vladimir, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Veterinarski fakultet, Zagreb
Profili:
Renata Barić-Rafaj
(autor)
Alan Kovačević
(autor)
Anita Horvatić
(autor)
Vladimir Mrljak
(autor)
Ivana Rubić
(autor)
Petra Nižić
(autor)
Josipa Kuleš
(autor)
Ines Jović
(autor)