Pregled bibliografske jedinice broj: 1161771
Timeliness of antiretroviral therapy initiation in the era before universal treatment
Timeliness of antiretroviral therapy initiation in the era before universal treatment // Scientific reports, 11 (2021), 10508, 12 doi:10.1038/s41598-021-90043-7 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1161771 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Timeliness of antiretroviral therapy initiation in
the era before universal treatment
Autori
Bogdanić, Nikolina ; Bendig, Liam ; Lukas, Davorka ; Zekan, Šime ; Begovac, Josip
Izvornik
Scientific reports (2045-2322) 11
(2021);
10508, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ART ; Croatia
Sažetak
We assessed the prevalence and factors related to the time to antiretroviral (ART) initiation among persons who entered HIV care and subsequently started ART in Croatia from 2005 to 2014. Included were patients ≥ 18 years, the follow-up ended on Dec/31/2017. 628 patients were included into the study 91.9% were men ; median age was 36.1 (Q1-Q3: 29.6-43.8) years. Rapid (within 7 days of diagnosis) ART initiation was observed in 21.8% patients, 49.8% initiated ART within 30 days, 21.7% and 28.5% had intermediate (31 days-1 year) and late initiation (> 1 year), respectively. Of 608 patients that achieved an undetectable viral load, 94% had a plasma HIV-1 RNA < 50 copies/ml at last measurement after a median follow-up of 5.2 years. On quantile regression analysis, calendar year of entry into care, and markers of more advanced HIV disease (higher viral load, lower CD4 cell count and clinical AIDS) were significantly associated with earlier ART initiation. Early ART was not related to a gap in care afterwards at all quantiles. In conclusion, a significant proportion of patients started ART early in Croatia in 2005- 2014. Early ART initiation led to durable viral load suppression and was not associated with a subsequent gap in care.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE