Naslov
Heterobimetallic Transition Metal Complexes of 1,2,3- Triazole Ligands

Autori
Jakopec, Silvio ; Pantalon Juraj, Natalija ; Brozovic, Anamaria ; Gasser, Gilles ; Perić, Berislav ; Kirin, Srećko I. ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
5th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry : Book of Abstracts / Gabelica Marković, Vesna - Zagreb : Gabelica Marković, Vesna, 2021, 4-4

Skup
5th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry

Mjesto i datum
Zagreb, Hrvatska, 30.11.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
1, 2, 3-triazole ; ferrocene ; transition metal complex

Sažetak
Organometallic and metal-based complexes have been widely used in drug discovery and some of them have entered clinical trials for the treatment of cancer. Design of new chemotherapy agents based on metal complexes is a fast-growing research area in which the biological activity of antitumor agents is based on metal-specific modes of action.1 The ferrocene pharmacophore is often introduced into the structure of drug-like molecules and bioactive hybrids with the aim of improvement of physicochemical properties and potency. In continuation of our research on coordination of mono- and bis-1, 2, 3-triazole derivatives, 2 we have synthesized and characterised ferrocene ligands as well as their Zn(II) and Cu(II) complexes by NMR, IR and UV-Vis spectroscopy and SC- XRD. Cytotoxic activity of N-heterocyclic ferrocene derivatives and their Zn(II) and Cu(II) complexes was evaluated.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA