Pregled bibliografske jedinice broj: 1160461
Prognostic role of CD44 expression and neovascularization determined by endoglin (CD105) in glioblastoma patients
Prognostic role of CD44 expression and neovascularization determined by endoglin (CD105) in glioblastoma patients // Acta clinica Croatica, 58 (2019), 3; 455-462 doi:10.20471/acc.2019.58.03.08 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1160461 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Prognostic role of CD44 expression and
neovascularization determined by endoglin (CD105)
in glioblastoma patients
(Prognostic role of CD44 expression and
neovascularization determined by endoglin (CD105)
in glioblastoma
patients)
Autori
Mihić, Josip ; Rotim, Krešimir ; Vučić, Majda ; Hude Dragičević, Ida ; Borić, Marta ; Lugović- Mihić, Liborija
Izvornik
Acta clinica Croatica (0353-9466) 58
(2019), 3;
455-462
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
glioblastoma ; brain neoplasms ; prognosis ; immunohistochemistry ; CD44 protein ; human ; endoglin
Sažetak
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Clinically useful molecular markers that help predict response to therapy and prognosis are still rare. The research was conducted in 55 patients with GBM, 26 (47.3%) women and 29 (52.7%) men, mean age 62.58 years. On immunohistochemical analysis, primary antibody to CD44 (dilution 1:50) and primary antibody to endoglin (CD105) (dilution 1:250) were used to evaluate neovascularization. Statistical analysis showed negative correlation between CD44 and survival (p=0.023) (higher expression of CD44 was correlated with shorter survival), but there was no correlation between neovascularization determined by CD105 in GBM and patient survival. Thus, significant individual predictors of longer survival were lower expression of CD44 (p=0.004), higher Karnofsky score (p=0.045), and female gender (p=0.017). The results obtained suggested the possible role of CD44 in the progression and tumor neovascularization of GBM.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb,
Zdravstveno veleučilište, Zagreb
Profili:
Marta Borić Krakar
(autor)
Liborija Lugović Mihić
(autor)
Majda Vučić
(autor)
Krešimir Rotim
(autor)
Josip Mihić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE