Naslov
The effect of isoflurane and iron dextran on biochemical and inflammatory parameters of tissues and organs in rats

Autori
Odeh, Dyana ; Adrović, Emanuela ; Gaćina, Lydia ; Lesar, Nikola ; Oršolić, Nada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Immunology, Supplement S1 / - Online : John Wiley & Sons, 2021, 283-283

Skup
6th European Congress of Immunology

Mjesto i datum
Online, 01.09.2021. - 04.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Animal models, inflammatory disease, tissue damage and repair

Sažetak
Anesthetics are types of medicines in a gaseous, liquid or other form, whose function is the introduction and/or maintenance of anesthesia with the aim of facilitating surgical and other painful interventions. Isoflurane has rapid pharmacological activity and absorbance, and stimulates rapid recovery after anesthesia. Long- term exposure to anesthetic acts negatively on peripheral organs and tissues, stimulates inflammation, oxidative stress, necrosis, and apoptosis leading to neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Iron is an indispensable part of the living organism and the disorder of its homeostasis produces redox active iron that affects the formation of ROS, tissue injury, cell growth disorder, and ultimately the appearance of oxidative stress. The aim of the study was to investigate the effect of isoflurane itself and/or the combination of iron dextran on the level of oxidative stress and consequent inflammation on liver, spleen and kidney tissues. The obtained results indicate that long-term use of isoflurane and iron-dextran alone or in combination increases the level of oxidative stress and inflammation in the liver, kidney and spleen cells and leads to their impairment, indicating an increase in biochemical parameters in serum and hemolysis of erythrocyte.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA