Naslov
Anti‐cancer efficacy and systemic toxicity of resveratrol nanocrystals in mice

Autori
Ančić, Daniela ; Oršolić, Nada ; Odeh, Dyana ; Ramić, Snježana ; Adrović, Emanuela ; Đermanović, Matea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Immunology, Supplement S1 / - , 2021, 277-277

Skup
6th European Congress of Immunology

Mjesto i datum
Online, 01.09.2021. - 04.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cancer imunology, in vivo tumor models, microenvironment

Sažetak
There has been significant research interest in nanocrystals as a promising technology for improving therapeutic efficacy of poorly water‐soluble drugs such as resveratrol. Nevertheless, little is known about the interaction of nanocrystals with biological tissue, especially liver, kidney and tumor, since nanocrystals remain longer in tissue compared to the fluids. The need to understand potentially harmful side effects of resveratrol nanocrystals became clear, and our goal was to investigate the potential toxicity of resveratrol and its nanocrystals through biochemical, oxidative and histological changes of kidney, liver and tumor by monitoring apoptosis, necrosis and mitotic index. Tumor was caused by intraperitoneal injection of 2.5 x 10⁶ EAT cells into the abdominal cavity of Swiss albino mice. Treatment of animals with EAT tumor in groups was started the following day by injecting resveratrol or resveratrol nanocrystals in a dose of 25 and 50 mg/kg every other day for 14 days straight. Results show that resveratrol nanocrystals significantly inhibit proliferation of tumor cells in the abdominal cavity and reduce number of blood vessels in the peritoneum, but also show systemic toxicity and reduce overall survival of animals. Hepatocellular necrosis and apoptosis, hepatic fibrosis around the central vein and degeneration with minor fatty change are shown. In addition, inflammation with high mitotic index in kidney and renal glomerulus swelling have also been observed with slight elevation of some biochemical parameters in groups on high‐dose of resveratrol nanocrystals. With respect for human health and environmental safety, the mechanism of toxicity needs to be further clarified.

Izvorni jezik
Engleski

POVEZANOST RADA