Naslov
The impact of asthma on quality of life and symptoms in patients with chronic rhinosinusitis

Autori
Penezić, Ana ; Paić, Matej ; Gregurić, Tomislav ; Grgić, Marko Velimir ; Baudoin, Tomislav ; Kalogjera, Livije

Izvornik
Current medical research and opinion (0300-7995) 36 (2020), 6; 1043-1048

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic rhinosinusitis (CRS) ; asthma ; polyposis ; allergy ; health-related quality of life (HRQL) ; osteitis

Sažetak
Objective: This study aims to evaluate how asthma influences clinical symptoms, imaging scores and health related quality of life (HRQL) in patients with chronic rhinosinusitis (CRS). Methods:The study enrolled 256 CRS patients and collected data about asthma status, clinical symptoms, allergic sensitization, computed tomography (CT) and 22- item SinoNasal Outcome questionnaire (SNOT-22). Matching pairs of asthmatic and non-asthmatic CRS patients were defined based on age, gender and nasal polyp presence. The difference between pairs in clinical symptoms, CT, and SNOT-22 was then analyzed. The study enrolled mild to moderate asthma patients. Results: Out of 256 patients asthma status was unknown in 6 patients and they were excluded. From 250 CRS patients 65 (26%) have had asthma. We found 60 CRS asthma and CRS non- asthma pairs based on age, gender and nasal polyp presence. There was no difference in total SNOT-22 score between asthma(46.45) and non-asthma(43.52) CRS groups(p<0.357). There were more patients with allergy positive medical history in asthma group (66.1%) when we stratified for CRS phenotypes, gender and age. Comparing visual analogue scale (VAS) scores for clinical symptoms, smell (p<0.013) was the only symptom significantly worse in the CRS asthma group. Although there was no difference in Lund-Mackay score, there was a higher osteitis score in the CRS asthma group almost reaching statistical significance (5.21 vs. 3.45 respectively ; p= 0.059). Conclusion: CRS patients with asthma have significantly impaired smell and taste. Aspirin intolerant, asthma positive CRS with nasal polyposis patients have significantly higher osteitis score when compared to other subgroups of CRS patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA