Pregled bibliografske jedinice broj: 1160064
Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives
Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 130-130 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 1160064 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Biological activity of benzimidazole and
benzothizole 2,5-disubstituted furane derivatives
Autori
Racané, Livio ; Zlatar, Ivo ; Perin, Nataša ; Cindrić, Maja ; Radovanović, Vedrana ; Banjanac, Mihailo ; Butković, Kristina ; Shanmugam, Suresh ; Radić Stojković, Marijana ; Brajša, Karmen ; Hranjec, Marijana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts
/ Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 130-130
Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog
Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
amidines ; acrylonitriles ; benzimidazoles ; benzothiazoles ; furanes ; antitumor activity ; DNA binding
Sažetak
Among all known nitrogen heterocycles, benzimidazole and benzothiazole moieties have been recognized as important and well-known constituents of biologically important molecules in medicinal and pharmaceutical chemistry [1, 2]. Due to their wide range of biological activities, these heterocycles are still unavoidable structural motifs in the rational design of novel drugs. Newly designed and synthesized cyano, amidino and acrylonitrile 2, 5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for antitumor and antimicrobial activity, as well as for their interaction with ct-DNA. Compounds 5, 6, 8, 9 and 15 showed high potential antitumor activity on three human lung cancer cell lines and high activity against S. cerevisiae as a eukaryotic model organism. DNA study showed that all compounds dominantly bind inside the minor groove of AT-rich DNA.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-4379 - Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot) (Hranjec, Marijana, HRZZ - 2018-01) ( CroRIS)
--IP-2018-01-4694 - Molekularno prepoznavanje DNA:RNA hibridnih i višelančanih struktura u bioanalitičkim i in vitro sustavima (DNARNAHyB-MolBio) (Radić Stojković, Marijana) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.
Profili:
Mihailo Banjanac (autor)
Maja Cindrić (autor)
Marijana Radić Stojković (autor)
Kristina Butković (autor)
Karmen Brajša (autor)
Marijana Hranjec (autor)
Nataša Perin (autor)
Livio Racane (autor)