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Pregled bibliografske jedinice broj: 1160064

Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives


Racané, Livio; Zlatar, Ivo; Perin, Nataša; Cindrić, Maja; Radovanović, Vedrana; Banjanac, Mihailo; Butković, Kristina; Shanmugam, Suresh; Radić Stojković, Marijana; Brajša, Karmen; Hranjec, Marijana
Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 130-130 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1160064 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives

Autori
Racané, Livio ; Zlatar, Ivo ; Perin, Nataša ; Cindrić, Maja ; Radovanović, Vedrana ; Banjanac, Mihailo ; Butković, Kristina ; Shanmugam, Suresh ; Radić Stojković, Marijana ; Brajša, Karmen ; Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 130-130

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
amidines ; acrylonitriles ; benzimidazoles ; benzothiazoles ; furanes ; antitumor activity ; DNA binding

Sažetak
Among all known nitrogen heterocycles, benzimidazole and benzothiazole moieties have been recognized as important and well-known constituents of biologically important molecules in medicinal and pharmaceutical chemistry [1, 2]. Due to their wide range of biological activities, these heterocycles are still unavoidable structural motifs in the rational design of novel drugs. Newly designed and synthesized cyano, amidino and acrylonitrile 2, 5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for antitumor and antimicrobial activity, as well as for their interaction with ct-DNA. Compounds 5, 6, 8, 9 and 15 showed high potential antitumor activity on three human lung cancer cell lines and high activity against S. cerevisiae as a eukaryotic model organism. DNA study showed that all compounds dominantly bind inside the minor groove of AT-rich DNA.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-4379 - Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot) (Hranjec, Marijana, HRZZ - 2018-01) ( CroRIS)
--IP-2018-01-4694 - Molekularno prepoznavanje DNA:RNA hibridnih i višelančanih struktura u bioanalitičkim i in vitro sustavima (DNARNAHyB-MolBio) (Radić Stojković, Marijana) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Tekstilno-tehnološki fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.

Poveznice na cjeloviti tekst rada:

27hskiki.hkd.hr

Citiraj ovu publikaciju:

Racané, Livio; Zlatar, Ivo; Perin, Nataša; Cindrić, Maja; Radovanović, Vedrana; Banjanac, Mihailo; Butković, Kristina; Shanmugam, Suresh; Radić Stojković, Marijana; Brajša, Karmen; Hranjec, Marijana
Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives // 27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 130-130 (poster, domaća recenzija, sažetak, znanstveni)
Racané, L., Zlatar, I., Perin, N., Cindrić, M., Radovanović, V., Banjanac, M., Butković, K., Shanmugam, S., Radić Stojković, M., Brajša, K. & Hranjec, M. (2021) Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives. U: Marković, D., Meštrović, E., Namjesnik, D. & Tomašić, V. (ur.)27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts.
@article{article, author = {Racan\'{e}, Livio and Zlatar, Ivo and Perin, Nata\v{s}a and Cindri\'{c}, Maja and Radovanovi\'{c}, Vedrana and Banjanac, Mihailo and Butkovi\'{c}, Kristina and Shanmugam, Suresh and Radi\'{c} Stojkovi\'{c}, Marijana and Braj\v{s}a, Karmen and Hranjec, Marijana}, year = {2021}, pages = {130-130}, keywords = {amidines, acrylonitriles, benzimidazoles, benzothiazoles, furanes, antitumor activity, DNA binding}, title = {Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives}, keyword = {amidines, acrylonitriles, benzimidazoles, benzothiazoles, furanes, antitumor activity, DNA binding}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }
@article{article, author = {Racan\'{e}, Livio and Zlatar, Ivo and Perin, Nata\v{s}a and Cindri\'{c}, Maja and Radovanovi\'{c}, Vedrana and Banjanac, Mihailo and Butkovi\'{c}, Kristina and Shanmugam, Suresh and Radi\'{c} Stojkovi\'{c}, Marijana and Braj\v{s}a, Karmen and Hranjec, Marijana}, year = {2021}, pages = {130-130}, keywords = {amidines, acrylonitriles, benzimidazoles, benzothiazoles, furanes, antitumor activity, DNA binding}, title = {Biological activity of benzimidazole and benzothizole 2,5-disubstituted furane derivatives}, keyword = {amidines, acrylonitriles, benzimidazoles, benzothiazoles, furanes, antitumor activity, DNA binding}, publisher = {Hrvatsko kemijsko dru\v{s}tvo}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }




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