Pregled bibliografske jedinice broj: 1159872
Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors
Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors // 27th Croatian Meeting of Chemists and Chemical Engineers : Book of abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Hrvatsko kemijsko društvo, 2021. str. 145-145 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1159872 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Novel iminocoumarin derived imidazo[4,5-b]pyridines
as potential pH sensors
Autori
Boček, Ida ; Vianello, Robert ; Hranjec, Marijana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers : Book of abstracts
/ Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 145-145
Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
imidazo[4, 5-b]pyridines ; iminocoumarines ; pH sensors, spectroscopic characterization ; computational chemistry
Sažetak
Benzazoles and coumarins are among the most privileged heterocyclic subunits in the medicinal chemistry due to their wide range of bioactivity. Iminocoumarine derivatives are known for their interesting spectroscopic properties as well as their application as fluorescent sensors. Monitoring pH range is crucial for studying many biological processes in live cell organelles. Conjugates of benzazoles and iminocoumarins are already being explored for pH sensing applications due to excellent spectroscopic response in correlation with pH value. This work presents the synthesis and spectroscopic characterization of novel iminocoumarine derived imidazo[4, 5- b]pyridines. Main percursor, 2- cyanomethylimidazo[4, 5-b]pyridine, was prepared in the cyclocondensation reaction with 2- cyanoacetamide, while targeted iminocoumarine derivatives were prepared in condensation with chosen 5-substituted salycil benzaldehydes. Nitro- substituted iminocoumarin was further condensed with 5-nitrosalycilbenzaldehid in order to explore additional conjugation on spectroscopic and pH sensing properties. The structures of newly prepared compounds were confirmed by means of 1H and 13C NMR spectroscopy as well as MS spectrometry. pH spectroscopic titrations will be performed in order to determine possible application as pH sensors in solutions followed by determination of pKa values experimentally as well as by computational approaches.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2020-02-8090 - Dizajn, sinteza i računalna analiza novih optičkih kemijskih pH osjetilnih derivata benzazola (BenzpHSens) (Vianello, Robert, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
