Naslov
Synthesis and bilogical activity of novel amidino- substituted benzimidazoles and benzothiazoles

Autori
Beč, Anja ; Žonja, Lucija ; Hranjec, Marijana ; Starčević, Kristina ; Persoons, Leentje ; Daelemans, Dirk

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The 27th Croatian Meeting of Chemists and Chemical Engineers / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 143-143

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
benzimidazoles, benzothiazoles, amidines, antioxidative activity, antiproliferative activity

Sažetak
Benzimidazole and benzothiazole are important scaffolds in pharmaceutical applications, associated with a wide variety of medicinal and biological activities. Amidine substituents at the termini of the molecule seem to contribute significantly to the molecule - possible biological target complex stability through H- bonding and electrostatic interactions [1]. This work presents the synthesis of novel amidino- substituted coumarine derived benzimidazoles and benzothiazoles as hydrochloride salts. Target compounds were prepared by conventional reactions of organic syntheses as well as by microwave assisted reactions. The synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, FRAP and ABTS, as well as antiproliferative activity on several human cancer cells in vitro [2].

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA