Naslov
Biological activities coumarinyl Schiff bases related to plant protection: Deeper insight into the mechanism of action

Autori
Vesna, Rastija ; Karolina, Vrandečić ; Jasenka, Ćosić ; Gabriella, Kanižai Šarić ; Maja, Karnaš ; Mario, Komar ; Maja, Molnar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers, BOOK OF ABSTRACTS / - Zagreb, 2021, 116-116

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Coumarins ; Schiff bases ; plant pathogenic fungi ; molecular docking

Sažetak
Coumarins, secondary plant metabolites[1] and their derivatives demonstrated a wide range of biological activities on different organisms (invertebrate pests, pathogenic fungus and other microorganisms and weeds. The aim was to study the inhibitory effects of coumarinyl schiff bases on the on the four cultures of plant pathogenic fungi (Macrophomina phaseolina, Sclerotinia sclerotiorum, Fusarium oxysporum f. sp. lycopersici, F. culmorum), as well as against two beneficial soil of bacteria (Bacillus mycoides and Bradyrhizobium japonicum). The radial growth of the fungal colonies was measured 48 h after inoculation. Coumarin derivatives were most effective were against M. phaseolina, but were not harmful against beneficial bacteria. The most effective compound against M. phaseolina was 4-bromophenyl-1-p-tolyl-1H-pyrazol derivatives of 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetohydrazide (4) (71.51 % inhibition). In order to determine the possible mechanism of action of coumarin derivatives against pathogenic fungi, molecular docking study has been performed on three enzymes responsible for the fungal growth: demethylase (pdb ID: 5eah) ; chitinase (pdb ID: 4txe) ; transferase (pdb ID: 2p6g) ; and the three plant cell wall-degrading enzymes: endoglucanase I (pdb ID: 2ovw) ; proteinase K (pdb ID: 2pwb) [53] ; pectinase (pdb ID: 1czf). Analyzed coumarin derivatives are promising candidates for developing plant protection products that could be safe for the environment, human health, and non-target organisms.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Poljoprivreda (agronomija)

POVEZANOST RADA