Naslov
Antibody response and self-reported adverse reactions following vaccination with Comirnaty: a pilot study from a Croatian university hospital

Autori
Lapić, Ivana ; Rogić, Dunja ; Šegulja, Dragana ; Zaninović, Ljiljana

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Journal of clinical pathology (2021)

Status rada
Online first

Ključne riječi
COVID-19 vaccines ; spike glycoprotein ; neutralizing antibodies ; serologic testing ; adverse reaction

Sažetak
This study aimed to determine antibody responses against SARS-CoV-2 spike (S) after both BioNTech– Pfizer Comirnaty vaccine doses and study the correlation with self-perceived adverse reactions. Antibodies determination with Elecsys anti-SARS- CoV-2 S assay was performed a day prior to or just before administration of the second dose and 8–13 days after the second dose. Participants selected from a predefined list of the experienced local (injection site reactions) and/or systemic (fatigue, headache, myalgia, arthralgia, chills and fever) post-vaccination adverse reactions. An average 100-fold increase in antibody titre in naive vaccinees was observed between the two time points (median 67 U/mL vs 2841 U/mL, p<0.001). Participants aged below 50 had higher antibody titres (median 99 U/mL vs 26 U/mL, p=0.003 after the first dose ; median 3617 U/mL vs 2556 U/mL, p=0.026 after the second dose). All reported adverse reactions were mild-to-moderate, with more participants declaring systemic reactions after the second dose (p=0.001), without a clear correlation with antibody titre.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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