Naslov
Retrospective study of toxicities associated with chemotherapy in dogs with ulticentric lymphoma treated at the Clinic for internal medicine, Faculty of veterinary medicine, University of Zagreb (2005-2021)
(Retrospective study of toxicities associated with chemotherapy in dogs with ulticentric lymphoma treated at the Clinic for internal medicine, Faculty of veterinary medicine, University of Zagreb (2005-2021))

Autori
Dodig, Tea ; Brkljačić, Mirna ; Crnogaj, Martina ; Filipčić, Ivana ; Gotić, Jelena ; Jović, Ines ; Šmit, Iva ; Torti, Marin ; Kučer, Nada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2021, 82-82

Skup
9th International Congress Veterinary Science and Profession

Mjesto i datum
Zagreb, Hrvatska, 09.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
multicentric lymphoma ; dog ; toxicities

Sažetak
Systemic chemotherapy is the therapy of choice for canine multicentric lymphoma. While implementing a chemotherapeutic protocol, it is important to inform the owners about the possible side effects which could interfere with the patient’s life quality. Chemotherapeutics can be associated with numerous toxicities. In most cases, toxicities are acute, but chronic or delayed effects do occur. The most common toxicities include bone marrow suppression, gastrointestinal injury, alopecia and other drug- specific toxicities (e.g. cardiotoxicity from doxorubicin). All of the documented toxicities are associated with dosage, concurrent diseases/organ dysfunction, specific breeds, idiosyncratic reactions and/or drug specifics. The aim of this study was to investigate the most common toxicities and their prevalence in the population of dogs with multicentric lymphoma treated at the Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, from 2005-2021. Thirty two dogs (15 females, 17 males) were diagnosed with multicentric lymphoma on the basis of cytology (66%) or immunocytochemistry (34%) of fine needle lymph node aspirates. Different drugs according to multiple protocols were used: vincristine (100%), doxorubicin (88%), cytarabine (66%), cyclophosphamide (50%), lomustin (13%), and metotrexate (3%). All of the dogs received prednisolone. Most common toxicities were neutropenia (28%) and gastrointestinal side effects (diarrhea 50%, nausea and vomiting 47%, inappetence 28%). Other included lethargy (13%), hemorrhagic cystitis (9%), local reaction after chemotherapeutic application (6%), skin erythema (6%) and fever (3%). Toxicities were most frequently seen with the use of vincristine (34%), followed by doxorubicin (28%) and cyclophosphamide (22%). In conclusion, noted toxicities were mild and self limiting with neutropenia and gastrointestinal side effects being the most common. The majority of toxicities was attributed to vincristine and doxorubicin.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA