Naslov
AGE-SPECIFIC EXCRETION OF CALCIUM, OXALATE, CITRATE, AND GLYCOSAMINOGLYCANS AND THEIR RATIOS IN HEALTHY CHILDREN AND CHILDREN WITH UROLITHIASIS

Autori
Turudic, Daniel ; Golubic, Anja Tea ; Bilic, Marko ; Milosevic, Danko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstracts of the 53rd ESPN Annual Meeting, Amsterdam, The Netherlands, September 2021 / - , 2021, 184-184

Skup
53rd Annual Scientific Meeting of ESPN

Mjesto i datum
Amsterdam, Nizozemska, 16.09.2021. - 19.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
calcium ; oxalate ; citrate ; glycosaminoglycans ; urolithiasis ; children

Sažetak
Introduction: We analyzed children with urolithiasis with age-and gender-matched healthy children as a retrospective study to ascertain any differences in urinary stone formation. Material and methods: We used 24-h urine of Ca mmol/mmol creatinine), Ox (mmol/mol cr), Cit (mmol/mol cr), GAGs (mg/mmol cr), Ca/ Cit (mol/mmol), Ox/GAGs (mmol/g), Ox/Cit (mmol/mmol), Ox/ (Cit×GAGs) (mol Ox × mol cr) / (mol Cit × g GAGs), and Cit/GAGs (mmol/g) were analyzed. Data analysis was performed by using Statistica for Windows version 8 and GraphPad Prism version 5. Additionally, J48 classifier was used to construct classification model for discrimination between subgroups. Results: Calcium (mmol/mmol creatinine) and the calcium/citrate ratio (mol/mmol) are the only variables that differentiate children before puberty from healthy children (ROC analysis confirmed only calcium/ citrate as a significant variable with cut-off value > 0.84). Pubertal /postpubertal children are distinguished from age- and gender-matched healthy children by the following variables: citrate (mmol / mol creatinine), calcium / citrate (mol / mmol), oxalate / glycosaminoglycans (mmol / g), oxalate / citrate ratios ( mmol / mmol) and oxalate / (citrate × glycosaminoglycans) (mol oxalate × mol creatinine) / (mol citrate × g glycosaminoglycans), all were confirmed by ROC analysis with cut-off values ≤ 327.87, > 1.02, > 11.24, > 0.12, > 0.03, respectively. Conclusions: These results indicate a different risk of urinary stones development before puberty vs. pubertal/postpubertal children and increasing importance (deficiency) of citrate and glycosaminoglycans in such children. J48 classifier confirmed the importance of the oxalate/ (citrate × glycosaminoglycans) and the calcium/citrate ratios with the practically applicable classification tree for distinguishing between pubertal/postpubertal children with urolithiasis with age-and gendermatched healthy children

Izvorni jezik
Engleski

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