Naslov
18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study
(18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study)

Autori
Mišir Krpan, Ana ; Hodolič, Marina ; Golubić, Anja Tea ; Baučić, Maja ; Nemir, Jakob ; Mrak, Goran ; Žuvić, Marijan ; Huić, Dražen

Izvornik
Croatian medical journal (0353-9504) 62 (2021), 4; 310-317

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
F-18-choline ; glioma ; F-18-FET

Sažetak
Aim: To investigate the diagnostic accuracy of O- (2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-dimethyl-2-hydroxyethyl- ammonium chloride (18F-FCH) computed tomography (CT) in patients with primary low-grade gliomas (LGG). Methods: The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent both 18F-FET and 18F-FCH positron emission tomography (PET)-CT. Brain PET- CT was performed according to standard protocol - 20 minutes after intravenous injection of 185 MBq of 18F-FET and 185 MBq of 18F-FCH PET. Surgery and pathohistological diagnosis were performed in the next two weeks. Results: We observed significantly better concordance between tumor histology and 18F-FET PET (weighted Kappa 0.74) compared with both 18F- FCH (weighted Kappa 0.15) and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18F-FET (odds ratio 12.87 ; 95% confidence interval [CI], 0.49-333.70 ; P=0.013, logistic regression analysis). Receiver operating characteristic curve analysis comparing 18F-FCH (area under the curve [AUC] 0.625, 95% CI 0.298- 0.884) and 18F-FET (AUC 0.833, 95% CI 0.499-0.982) showed better diagnostic properties of 18F-FET (AUC difference 0.208, 95% CI -0.145 to 0.562, P=0.248). Conclusion: Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18F-FET seems to be more accurate than 18F-FCH in the LGG diagnosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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