Naslov
Bone morphogenetic proteins, carriers, and animal models in the development of novel bone regenerative therapies

Autori
Štoković, Nikola ; Ivanjko, Natalia ; Matičić, Dražen ; Luyten, Frank P. ; Vukičević, Slobodan

Izvornik
Materials (1996-1944) 14 (2021), 13; 3513, 23

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
animal model ; bone fracture ; bone healing ; posterolateral spinal fusion ; regenerative medicine ; bone morphogenetic proteins

Sažetak
Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone formation. Numerous preclinical studies have been conducted to develop novel, BMP-based osteoinductive devices for the management of segmental bone defects and posterolateral spinal fusion (PLF). In these studies, BMPs were combined with a broad range of carriers (natural and synthetic polymers, inorganic materials, and their combinations) and tested in various models in mice, rats, rabbits, dogs, sheep, and non-human primates. In this review, we summarized bone regeneration strategies and animal models used for the initial, intermediate, and advanced evaluation of promising therapeutical solutions for new bone formation and repair. Moreover, in this review, we discuss basic aspects to be considered when planning animal experiments, including anatomical characteristics of the species used, appropriate BMP dosing, duration of the observation period, and sample size.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA