Naslov
Probiotics: from mother's milk microbiota to novel food supplements and live biotherapeutics

Autori
Kos, Blaženka ; Šušković, Jagoda ; Novak, Jasna ; Leboš Pavunc, Andreja ; Žučko, Jurica ; Banić, Martina ; Butorac, Katarina ; Čuljak, Nina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the 13th International Scientific and Professional Conference WITH FOOD TO HEALTH / Jozinović, Antun ; Babić, Jurislav ; Šubarić, Drago ; Jašić, Midhat - Osijek : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Tehnološki fakultet Univerziteta u Tuzli, 2021, 3-3

ISBN
978-953-7005-79-5

Skup
13. međunarodni znanstveno-stručni skup: hranom do zdravlja = 13th International Scientific and Professional Conference: With food to health

Mjesto i datum
Osijek, Hrvatska, 16.09.2021. - 17.09.2021

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mother's milk microbiota ; next-generation of probiotics ; S-layer proteins ; bacteriocins ; exopolysaccharides

Sažetak
Mother's milk contains a diverse range of lactic acid bacteria (LAB) which have an emerging role in the establishment of the gut neonatal microbiota and have a huge potential as a next-generation of probiotics. Microbiomes analyses by QIIME2 bioinformatics platform, shown correlation between faeces microbiota composition of infant and their mother's milk. Unique autochthonous strains of LAB, isolated from the microbiota of mothers' milk, produce specific metabolites with potential therapeutic properties, such as surface S-layer proteins (Slps), bacteriocins and exopolysaccharides (EPS) which have an impact on their activity as probiotics in food supplements and as live biotherapeutics. According to our research results, Slps and EPS enhance survival of probiotics during biotechnological production by freeze-drying and gastrointestinal transit, prolong residence time in the colon of the host with potential immunomodulatory activity. Additionally, EPS are prebiotic supstrates for the gut microbiota - producers of short-chain fatty acids and lactate, metabolites with antibacterial activity, immune system modulation, enegry supply for the intestinal epithelial cells, and the modulation of cholesterol and lipid metabolism. Bacteriocins, as well as Spls and EPS, promote competitive exclusion od pathogens, whereas bacteriocins display antimicrobial activity. The huge potential of next-generation of probiotics as live biotherapeutics and food supplements is recognised for re-establishing of disturbed balance of intestinal microbiota, with potential therapeutic effect on obesity, mood, metabolic disorders, autoimmune diseases and female urogenital infections. Therefore, pharmaceutical and food companies founded large microbiome research centres for the development of next-generation of probiotics with predicted microbiota medicines market of over 500 million EUR by the year of 2030.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

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