Pregled bibliografske jedinice broj: 1155060
Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury // Frontiers in Integrative Neuroscience, 15 (2021), 758340, 7 doi:10.3389/fnint.2021.758340 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 1155060 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Circular RNAs: The Novel Actors in Pathophysiology
of Spinal Cord Injury
Autori
Sámano, Cynthia ; Mladinic, Miranda ; Mazzone, Graciela Luján
Izvornik
Frontiers in Integrative Neuroscience (1662-5145) 15
(2021);
758340, 7
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
spinal cord injury ; circRNAs ; biomarkers ; non-coding RNA ; circRNAs in central nervous system
Sažetak
Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex gene alterations and activation of the neuroimmune system influence either cell damage or repair. Effective therapies to avoid secondary mechanisms underlying SCI are still lacking. The recent progression in circular RNAs (circRNAs) research has drawn increasing attention and opened a new insight on SCI pathology. circRNAs differ from traditional linear RNAs and have emerged as the active elements to regulate gene expression as well as to facilitate the immune response involved in pathophysiology- related conditions. In this review, we focus on the impact and possible close relationship of circRNAs with pathophysiological mechanisms following SCI, where circRNAs could be the key transcriptional regulatory molecules to define neuronal death or survival. Advances in circRNAs research provide new insight on potential biomarkers and effective therapeutic targets for SCI patients.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-7060 - Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca (DefineREgenAgeMode) (Mladinić Pejatović, Miranda, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
Profili:
Miranda Mladinić Pejatović
(autor)
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.frontiersin.org pubmed.ncbi.nlm.nih.govCitiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus