Naslov
Prenatal exposure to α-cypermethrin and endocrine disruption in mother rats and foetuses at term

Autori
Katić, Anja ; Sulimanec Grgec, Antonija ; Micek, Vedran ; Merčep, Antonia ; Bošnjaković, Anja ; Biličić, Lea ; Canjuga, Irena ; Lucić Vrdoljak, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 6th Croatian Congress of Toxicology with International Participation CROTOX 2021 ; u: Arhiv za higijenu rada i toksikologiju 72 (2021) (S1) / Lyons, Daniel Mark - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2021, 41-41

Skup
6th Croatian congress of toxicology with international participation (CROTOX 2021)

Mjesto i datum
Rabac, Hrvatska, 03.10.2021. - 06.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
endocrine disrupting chemical ; gravid uterus ; in utero exposure ; ovaries ; pyrethroid insecticide

Sažetak
α-cypermethrin (α-cyp) is a synthetic pyrethroid insecticide widely used in and around households, as well as in agriculture and veterinary applications due to its rapid degradation rate and low mammalian toxicity. Due to the fact that pyrethroids are one of the most used groups of insecticides worldwide and can act as endocrine disrupting chemicals, we investigated the effects of prenatal exposure to α- cyp on endocrine disruption parameters in rat mothers and foetuses at term. Pregnant Wistar rats were orally exposed from the 6th day of gestation (DG) to the 21st to α-cyp at 1, 10, and 19 mg/kg bw/day, diethylsilbestrol as positive control, corn oil as solvent control, and water as negative control. At the 21st DG, gravid uterus and ovaries were dissected under general anaesthesia and parameters of endocrine disruption were monitored according to adequate OECD protocols. No differences were found in the number of corpora lutea in the ovaries. The number of implants, live or dead foetuses, as well as of early and late resorptions did not change between groups. No changes in the number and weight of male and female foetuses were noticed. Male to female foetal sex ratio (% per litter) was approximately 70 to 30 % in the rats treated with α-cyp at 1 and 10 mg/kg bw/day and diethylsilbestrol, while about 40 to 60 %in negative and solvent control. Our findings suggest that α-cyp at the applied exposure scenarios and doses did not act as an endocrine disruptor in mother rats and foetuses.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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