Naslov
Effects of irinotecan and Δ9-tetrahydrocannabinol on tumour growth and weights in a mouse syngeneic model of colon cancer

Autori
Katić, Anja ; Žunec, Suzana ; Kopjar, Nevenka ; Brčić Karačonji, Irena ; Jurič, Andreja ; Micek, Vedran ; Neuberg, Marijana ; Lucić Vrdoljak, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 6th Croatian Congress of Toxicology with International Participation CROTOX 2021 ; u: Arhiv za higijenu rada i toksikologiju 72 (2021) (S1) / Lyons, Daniel Mark - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2021, 41-41

Skup
6th Croatian congress of toxicology with international participation (CROTOX 2021)

Mjesto i datum
Rabac, Hrvatska, 03.10.2021. - 06.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
body weights ; cancer therapy ; cannabinoid-based preparations ; organ weights ; tumour size

Sažetak
Colon cancer is one of the most common cancers and causes of death worldwide. The aim of this study was to investigate the effects of the concomitant intake of Δ9-tetrahydrocannabinol (THC) and cytostatic irinotecan (IRI) on tumour growth and body and organ weights in mice with experimental colon cancer induced by an injection of the CT26 cell line. Male BALB/c mice (N=5 per group) were randomly assigned to the following groups: IRI (60 mg/kg b.w., i.p., 1st and 5th day of the experiment), THC (7 mg/kg b.w., p.o., consecutively during the 7-day experimental period), combination of IRI and THC, solvent control (sesame oil, p.o., consecutively during the 7-day experimental period), and cancer control (without treatment). Weight and tumour measurements were performed every other day throughout the experiment. Mice were sacrificed on the seventh day and tissue samples were dissected and weighed. Body weights decreased significantly in IRI and IRI-THC treated mice on the third day as well as in IRI-THC treated mice on the seventh day compared to THC-treated and cancer control mice. There were no significant changes in brain and liver relative weights between the experimental groups. The tumours grew constantly over time with significant differences in growth between the third and seventh day in all groups. Differences in tumour size between experimental groups were not observed. The present study showed that IRI exposure affected body weights when applied alone or in combination with THC and that neither single IRI, single THC or combined exposure affected tumour growth under these experimental conditions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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