Naslov
Stability of amidino substituted benzothiazole derivatives with antitumor activity

Autori
Mutavdžić Pavlović, Dragana ; Tolić, Kristina ; Gazivoda Kraljević, Tatjana ; Hranjec, Marijana ; Racané, Livio ; Pocrnić, Marijana ; Galić, Nives ; Runje, Mislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 49-49

Skup
27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
forced degradation, benzothiazoles, mass spectrometry

Sažetak
This study focused on the forced degradation tests as one of the routine stability testing methods in the pharmaceutical industry to investigate the stability of benzothiazoles. In recent years, these newly synthesized compounds have attracted attention in medicinal chemistry as potential biological agents with antitumor activity. In general, the performance of stress tests according to the guideline ICH [1] is necessary with the aim of determining and characterizing newly formed by- products (organic, inorganic) that may ultimately affect the safety and efficacy of the active ingredients. In order to investigate the intrinsic stability and possibly identify newly formed degradation products, some amidino-substituted benzothiazol compounds were exposed to different environmental conditions. Photolytic, hydrolytic, oxidative and thermal degradation of the main compound were applied. High resolution mass spectrometry technique (UHPLC-QTOF- MS /MS) was used for separation, identification and characterization of the above compounds. Based on the spectral data obtained, preliminary structures of the major degradation products with proposed degradation pathways of the identified products were given. REFERENCES [1] International Conference on Harmonization (ICH), Stability Testing of new drug substances and products, Q1A (R2), IFPMA, Geneva, 2003.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA