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Pregled bibliografske jedinice broj: 1154155

Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells

Domijan, Ana-Marija; Hercog, Klara; Filipič, Metka; Sokolović, Marijana; Gerić, Marko; Gajski, Goran; Žegura, Bojana
Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells // Arhiv za higijenu rada i toksikologiju / Lyons, Daniel M. (ur.).
Zagreb: Institut za medicinska istraživanja i medicinu rada, 2021. str. 60-60 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 1154155 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells

Autori
Domijan, Ana-Marija ; Hercog, Klara ; Filipič, Metka ; Sokolović, Marijana ; Gerić, Marko ; Gajski, Goran ; Žegura, Bojana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju / Lyons, Daniel M. - Zagreb : Institut za medicinska istraživanja i medicinu rada, 2021, 60-60

Skup
6th Croatian congress of toxicology with international participation (CROTOX 2021)

Mjesto i datum
Rabac, Hrvatska, 03.10.2021. - 06.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
mycotoxins ; co-exposure ; cytotoxicity ; genotoxicity ; comet assay

Sažetak
The aim of the study was to evaluate cytotoxic and genotoxic activity of mycotoxins, deoxynivalenol (DON) and zearalenone (ZEA), two common contaminants of food and feed found worldwide. Human hepatocellular carcinoma (HepG2) cells were treated with DON (0.25 - 16 μM), ZEA (1.25 - 80 μM) or their combination (1 μM + 5 μM ; 1 μM + 10 μM or 1 μM + 20 μM) for 24 h, and cell viability was assessed with the MTS assay. For genotoxicity experiments cells were treated with DON (0.5, 1 and 2 μM), ZEA (5, 10 and 20 μM) or their combination (1 μM + 5 μM ; 1 μM + 10 μM or 1 μM + 20 μM) for 24 h, and the comet assay was performed. DON (2 μM) and ZEA (80 μM) reduced cell viability to 70.5 % and 55.2 %, respectively, while combined exposure reduced cell survival from 16.2 to 24.5 % (P < 0.05). Results imply that both mycotoxins are cytotoxic for HepG2 cells. DON and ZEA in single and combined exposure did not increase % of tail DNA (P > 0.05), suggesting that these two mycotoxins do not induce DNA single strand breaks. Due to climatic changes and global food trade humans can be repeatedly exposed to DON and ZEA as well as their combinations ; therefore, the underlying mechanisms of their single and combined toxicity have to be further explored.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Hrvatski veterinarski institut, Zagreb

Profili:

Avatar Url Marko Gerić (autor)

Avatar Url Marijana Sokolovic (autor)

Avatar Url Ana-Marija Domijan (autor)

Avatar Url Goran Gajski (autor)

Citiraj ovu publikaciju:

Domijan, Ana-Marija; Hercog, Klara; Filipič, Metka; Sokolović, Marijana; Gerić, Marko; Gajski, Goran; Žegura, Bojana
Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells // Arhiv za higijenu rada i toksikologiju / Lyons, Daniel M. (ur.).
Zagreb: Institut za medicinska istraživanja i medicinu rada, 2021. str. 60-60 (poster, međunarodna recenzija, sažetak, znanstveni)
Domijan, A., Hercog, K., Filipič, M., Sokolović, M., Gerić, M., Gajski, G. & Žegura, B. (2021) Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells. U: Lyons, D. (ur.)Arhiv za higijenu rada i toksikologiju.
@article{article, author = {Domijan, Ana-Marija and Hercog, Klara and Filipi\v{c}, Metka and Sokolovi\'{c}, Marijana and Geri\'{c}, Marko and Gajski, Goran and \v{Z}egura, Bojana}, editor = {Lyons, D.}, year = {2021}, pages = {60-60}, keywords = {mycotoxins, co-exposure, cytotoxicity, genotoxicity, comet assay}, title = {Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells}, keyword = {mycotoxins, co-exposure, cytotoxicity, genotoxicity, comet assay}, publisher = {Institut za medicinska istra\v{z}ivanja i medicinu rada}, publisherplace = {Rabac, Hrvatska} }
@article{article, author = {Domijan, Ana-Marija and Hercog, Klara and Filipi\v{c}, Metka and Sokolovi\'{c}, Marijana and Geri\'{c}, Marko and Gajski, Goran and \v{Z}egura, Bojana}, editor = {Lyons, D.}, year = {2021}, pages = {60-60}, keywords = {mycotoxins, co-exposure, cytotoxicity, genotoxicity, comet assay}, title = {Cytotoxic and genotoxic activity of Fusarium mycotoxins, deoxynivalenol and zearalenone in HepG2 cells}, keyword = {mycotoxins, co-exposure, cytotoxicity, genotoxicity, comet assay}, publisher = {Institut za medicinska istra\v{z}ivanja i medicinu rada}, publisherplace = {Rabac, Hrvatska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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