Naslov
BPC 157 therapy and the permanent occlusion of the superior sagittal sinus in rat: vascular recruitment

Autori
Gojković, Slaven ; Krezić, Ivan ; Vraneš, Hrvoje ; Žižek, Helena ; Drmić, Domagoj ; Horvat Pavlov, Katarina ; Petrović, Andreja ; Batelja Vuletić, Lovorka ; Milavić, Marija ; Sikirić, Sunčana ; Stilinović, Irma ; Samara, Mariam ; Knežević, Mario ; Barišić, Ivan ; Sjekavica, Ivica ; Lovrić, Eva ; Škrtić, Anita ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Biomedicines (2227-9059) 9 (2021), 7; 744, 33

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BPC 157 ; superior sagittal sinus ; occlusion ; therapy ; vascular recruitment ; rats

Sažetak
We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and peripherally, with the stable gastric pentadecapeptide BPC 157, which alleviated peripheral vascular occlusion disturbances, rapidly activating alternative bypassing pathways. Assessments were gross recording, venography, ECG, pressure, microscopy, biochemistry. The increased pressure in the superior sagittal sinus, portal and caval hypertension, aortal hypotension, arterial and venous thrombosis, severe brain swelling and lesions (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus), particular veins (azygos, superior mesenteric, inferior caval) dysfunction, heart dysfunction, lung congestion as acute respiratory distress syndrome, kidney disturbances, liver failure, and hemorrhagic lesions in gastrointestinal tract were all assessed. Rats received BPC 157 medication (10 µg/kg, 10 ng/kg) intraperitoneally, intragastrically, or topically to the swollen brain at 1 min ligation-time, or at 15 min, 24 h and 48 h ligation-time. BPC 157 therapy rapidly attenuates the brain swelling, rapidly eliminates the increased pressure in the ligated superior sagittal sinus and the severe portal and caval hypertension and aortal hypotension, and rapidly recruits collateral vessels, centrally ((para)sagittal venous collateral circulation) and peripherally (left superior caval vein azygos vein-inferior caval vein). In conclusion, as shown by all assessments, BPC 157 acts against the permanent occlusion of the superior sagittal sinus and syndrome (i.e., brain, heart, lung, liver, kidney, gastrointestinal lesions, thrombosis), given at 1 min, 15 min, 24 h or 48 h ligation- time. BPC 157 therapy rapidly overwhelms the permanent occlusion of the superior sagittal sinus in ra

Izvorni jezik
Hrvatski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA