Naslov
Synthesis and enantioseparation of (±)- marinoaziridine precursors

Autori
Buljan, Anđela ; Sinković, Paola ; Roje, Marin

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 161-161

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epoksid ; , 2-kinolinoni ; kiralna nepokretna faza

Sažetak
Aziridines are an important class of molecules present as the key structural component in a number of biologically active natural products [1]. Apart from their pharmacological purposes, aziridines are also valuable from a synthetic point of view as they can function as building blocks for the synthesis of numerous biologically active and natural compounds [2]. Our interest was primarly focused on the construction of epoxides 1a-1c and 2a-2c as important precursors in the total synthesis of marinoaziridines A, B and their derivatives (Figure 1). Marinoaziridines A and B are the first aziridine-based alkaloids isolated from Gram-negative bacteria from marine sediment [3]. In conducted research the (±)-marinoaziridine precursors 1a-1c and 2a-2c were prepared by the addition of the achiral sulfur ylide derived from sulfonium salt I or II to a carbon-oxygen double bond of the corresponding aldehydes Ia-Ic in good yield.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA