Naslov
Non-Alcoholic Fatty Liver Disease and COVID-19–Two Pandemics Hitting at the Same Time

Autori
Vranić, Luka ; Radovan, Anja ; Poropat, Goran ; Mikolašević, Ivana ; Milić, Sandra

Izvornik
Medicina (1010-660X) 57 (2021), 10; 1-9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; liver injury ; metabolic-associated fatty liver disease ; metabolic syndrome ; non-alcoholic fatty liver disease

Sažetak
The COVID-19 pandemic was and still is a global burden with more than 178, 000, 000 cases reported so far. Although it mainly affects respiratory organs, COVID-19 has many extrapulmonary manifestations, including, among other things, liver injury. Many hypotheses have been proposed to explain direct and indirect impacts of the SARS-CoV-2 virus on the liver. Studies have shown that around 15–30% of patients with COVID-19 have underlying liver disease, and 20–35% of patients with COVID-19 had altered liver enzymes at admission. One of the hypotheses is reactivation of an underlying liver disease, such as non- alcoholic fatty liver disease (NAFLD). Some studies have shown that NAFLD is associated with severe COVID-19 and poor outcome ; nevertheless, other studies showed no significant difference between groups in comparing complications and clinical outcomes. Patients with NAFLD may suffer severe COVID-19 due to other comorbidities, especially cardiovascular diseases. The link between NAFLD and COVID-19 is not clear yet, and further studies and research are needed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA