Pregled bibliografske jedinice broj: 1152408
Different histological classifications for IgA vasculitis nephritis – which one has the best association with the disease outcome?
Different histological classifications for IgA vasculitis nephritis – which one has the best association with the disease outcome? // Archives of disease in childhood, 106 (2021), Suppl 2
Zagreb, Hrvatska, 2021. str. A185-A185 doi:10.1136/archdischild-2021-europaediatrics.443 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1152408 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Different histological classifications for IgA
vasculitis nephritis – which one has the best
association with the disease outcome?
Autori
Kifer, Nastasia ; Šestan, Mario ; Held, Martina ; Ćorić, Marijana ; Bulimbašić, Stela ; Giani, Teresa ; Martin, Neil ; Sršen, Saša ; Gudelj Gračanin, Ana ; Kifer, Domagoj ; Heshin, Merav ; Ravelli, Angelo ; Cimaz, Rolando ; Ozen, Seza ; Gagro, Alenka ; Jelušić, Marija
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Archives of disease in childhood, 106 (2021), Suppl 2
/ - , 2021, A185-A185
Skup
10th Congress of European Paediatric Association EPA/UNEPSA jointly held with 14 th Congress of Croatian Paediatric Society
Mjesto i datum
Zagreb, Hrvatska, 07.10.2021. - 09.10.2021
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
IgA vasculitis nephritis ; kidney biopsy ; classifications
Sažetak
IgA vasculitis nephritis (IgAVN) is almost the only cause of morbidity and mortality among children suffering from this most common childhood-vasculitis. Several histological classifications are used in the analysis of renal biopsy findings in IgAVN, but it remains unknown which one is the best predictor of severity and disease outcome. The aim was to compare the four most commonly used histologic classifications for IgAVN and to establish which variables of each histological classification have the strongest association with unfavorable outcome. The cross- sectional study included 74 patients with IgAVN (diagnosed by EULAR/PRES/PRINTO criteria) and available renal biopsy specimens for analysis using the four histological classifications for IgAVN (the International Study of Kidney Disease in Children (ISKDC) classification, the Oxford classification, the Haas histologic classification of IgA nephropathy and the modified semi- quantitative classification (SQC), developed by Koskela et al.). The clinical outcome was defined through four categories, graded according to the modified classification of Counahan (physical examination, hematuria, proteinuria, urine albumin-tocreatinine ratio, hypertension and eGFR). The linear relationships between outcome and histological classifications were analysed using ordinal regressions using the first-order of polynomial orthogonal contrasts. The SQC classification proved to be the best, reducing the deviation (of the model-predicted outcome value from the observed value) by 9.5% (c21=13, 89, p<0, 001), followed by the Oxford classification with a deviation reduction of 8.0% (c21=11, 76, p=0, 001), then the ISKDC classification with a decrease in deviation of 3.3% (c21=4, 89, p=0, 027). The worst was the Haas classification with a decrease in deviation of 2.1% (c21=3, 06, p=0, 080). Analysis of individual variables of Oxford and SQC classifications showed that with increasing values in the variables of interstitial fibrosis (t66=3, 23, p=0, 002), tubular atrophy (t66=2, 94, p=0, 005) and tubular dilatation (t66=2, 40, p=0, 019) in the SQC classification, and endocapillary hypercellularity (t66=3, 14, p=0, 003) and crescents (t66=2, 07, p=0, 043) in the Oxford classification the outcome worsens. This study showed that the SQC classification has the strongest association with the IgAVN severity and outcome. Although crescents on renal biopsy were considered the most important outcome indicators, our study suggests that tubulointerstitial changes could be more important as predictors of poor outcome. Interstitial and renal tubules changes should be further explored in order to have better predictive values of IgAVN outcome and to be incorporated into existing or new classifications, on the basis of which guidelines for the treatment of patients would be developed. SUPPORT: Croatian Science Foundation project IP- 2019-04-8822.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
IP-2019-04-8822 - Histološki, klinički, laboratorijski i genski prediktori ishoda bolesnika s Henoch-Schönleinovom purpurom i nefritisom (PURPURAPREDICTORS) (Jelušić, Marija, HRZZ - 2019-04) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Martina Held
(autor)
Mario Šestan
(autor)
Marijana Ćorić
(autor)
Domagoj Kifer
(autor)
STELA BULIMBAŠIĆ
(autor)
Nastasia Kifer
(autor)
Marija Jelušić
(autor)
Alenka Gagro
(autor)
Ana Gudelj Gračanin
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE