Pregled bibliografske jedinice broj: 1152355
Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3- triazole
Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3- triazole // Molecules, 26 (2021), 21; 6352, 13 doi:10.3390/molecules26216352 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1152355 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Design, Synthesis, and Biological Evaluation of
Desmuramyl Dipeptides Modified by Adamantyl-1,2,3-
triazole
Autori
Petrović Peroković, Vesna ; Car, Željka ; Draženović, Josip ; Stojković, Ranko ; Milković, Lidija ; Antica, Mariastefania ; Škalamera, Đani ; Tomić, Srđanka ; Ribić, Rosana
Izvornik
Molecules (1420-3049) 26
(2021), 21;
6352, 13
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
mannose ; desmuramyl peptide ; adamantyl-triazole ; immunostimulant activity
Sažetak
Muramyl dipeptide (MDP) is the smallest peptidoglycan fragment able to trigger the immune response. Structural modification of MDP can lead to the preparation of analogs with improved immunostimulant properties, including desmuramyl peptides (DMPs). The aim of this work was to prepare the desmuramyl peptide (L-Ala-D-Glu)- containing adamantyl-triazole moiety and its mannosylated derivative in order to study their immunomodulatory activities in vivo. The adjuvant activity of the prepared compounds was evaluated in a murine model using ovalbumin as an antigen, and compared to the reference adjuvant ManAdDMP. The results showed that the introduction of the lipophilic adamantyl-triazole moiety at the C- terminus of L-Ala-D-Glu contributes to the immunostimulant activity of DMP, and that mannosylation of DMP modified with adamantyl- triazole causes the amplification of its immunostimulant activity.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-7899 - Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikonjugata (PEPTGLYCOSAR) (Tomić-Pisarović, Srđanka, HRZZ - 2014-09) ( CroRIS)
HRZZ-IP-2020-02-2431 - Obnova timusa za preciznu medicinu u liječenju tumora i leukemija (THYMINNOVA) (Antica, Mariastefania, HRZZ - 2020-02) ( CroRIS)
NadSve-Sveučilište Sjever-UNIN-BIOMED-20-1-1 - Priprava i ispitivanje bioloških svojstava muropeptida (Ribić, Rosana, NadSve - Natječaj za potpore znanstvenim istraživanjima i umjetničkom radu Sveučilišta Sjever u 2020. godini) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Sveučilište Sjever, Koprivnica
Profili:
Rosana Ribić
(autor)
Đani Škalamera
(autor)
Lidija Milković
(autor)
Mariastefania Antica
(autor)
Srđanka Tomić-Pisarović
(autor)
Željka Car
(autor)
Ranko Stojković
(autor)
Vesna Petrović-Peroković
(autor)
Josip Draženović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE