Naslov
Oxidation of L-DOPA and dopamine during gold clusters formation: NMR and computational study

Autori
Kalčec, Nikolina ; Ljulj, Antonio ; Božičević, Lucija ; Pem, Barbara ; Vrček, Valerije ; Vinković Vrček, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
The 18th European Symposium on Organic Reactivity

Mjesto i datum
Amsterdam, Nizozemska, 21.09.2021. - 23.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DOPA, dopamine, gold nanoparticles, NMR DFT

Sažetak
Due to their unique physical and chemical properties, gold nanoparticles (AuNPs) have been extensively used in biomedical fields, including drug delivery into the brain as they can easily penetrate through the blood-brain barrier. The study employed combined NMR and computational approach to study events at the nano-bio interface during preparation of L-DOPA/dopamine-functionalized AuNPs. During synthesis, LDOPA/dopamine were used as both reducens and surface coating agents, but mechanisms of their interaction with gold clusters and nanosurface have been not yet elucidated. Both dopamine and DOPA are oxidized in the course of Au cluster preparation, resulting in dopaminequineone and dopaquinone, resp. The latter undergoes intramolecular cyclization forming cyclodopa. All these intermediates are included in interactions with the AuNP surface.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA