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Pregled bibliografske jedinice broj: 1151904

Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS


Habinovec, Iva; Mikulandra, Ivana; Sekula, Lucia Ema; Gašperov, Jana; Kazazić, Saša; Novak, Predrag
Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS // Molecules, 26 (2021), 6316; 26206316, 11 doi:10.3390/molecules26206316 (međunarodna recenzija, članak, znanstveni)


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Naslov
Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS

Autori
Habinovec, Iva ; Mikulandra, Ivana ; Sekula, Lucia Ema ; Gašperov, Jana ; Kazazić, Saša ; Novak, Predrag

Izvornik
Molecules (1420-3049) 26 (2021), 6316; 26206316, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azithromycin conjugates ; macrozones ; HPLC-SPE/cryo NMR ; MS ; structure determination

Sažetak
LC-SPE/cryo NMR and MS methodologies have been developed and employed for a rapid structure determination of 4″-tetrahydrofurfuryl macrozone reaction mixture components. Macrozones, novel conjugates of azithromycin, and thiosemicarbazones have shown very good in vitro antibacterial activities against susceptible and some resistant bacterial strains and are promising agents for further development. The post-column multiple trapping of the chromatographically separated reaction mixture components on the SPE cartridges increased the sensitivity and together with cryogenically cooled NMR probe made it possible to identify and structurally characterize main 4″- tetrahydrofurfuryl macrozone reaction mixture compounds including those present at very low concentration level. This approach has several advantages over a classical off-line procedure, efficiency and low solvent consumption being the two most important ones. All identified components were process-related. It has been demonstrated that two different kinds of compounds with respect to structure were identified, i.e., macrolide- related and thiosemicarbazone-related ones. This methodology can serve as a platform for reliable and effective macrolides reaction components structure profiling, serving as both isolation and identification tools.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Iva Habinovec (autor)

Avatar Url Saša Kazazić (autor)

Avatar Url Ivana Mikulandra (autor)

Avatar Url Predrag Novak (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Habinovec, Iva; Mikulandra, Ivana; Sekula, Lucia Ema; Gašperov, Jana; Kazazić, Saša; Novak, Predrag
Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS // Molecules, 26 (2021), 6316; 26206316, 11 doi:10.3390/molecules26206316 (međunarodna recenzija, članak, znanstveni)
Habinovec, I., Mikulandra, I., Sekula, L., Gašperov, J., Kazazić, S. & Novak, P. (2021) Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS. Molecules, 26 (6316), 26206316, 11 doi:10.3390/molecules26206316.
@article{article, author = {Habinovec, Iva and Mikulandra, Ivana and Sekula, Lucia Ema and Ga\v{s}perov, Jana and Kazazi\'{c}, Sa\v{s}a and Novak, Predrag}, year = {2021}, pages = {11}, DOI = {10.3390/molecules26206316}, chapter = {26206316}, keywords = {azithromycin conjugates, macrozones, HPLC-SPE/cryo NMR, MS, structure determination}, journal = {Molecules}, doi = {10.3390/molecules26206316}, volume = {26}, number = {6316}, issn = {1420-3049}, title = {Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS}, keyword = {azithromycin conjugates, macrozones, HPLC-SPE/cryo NMR, MS, structure determination}, chapternumber = {26206316} }
@article{article, author = {Habinovec, Iva and Mikulandra, Ivana and Sekula, Lucia Ema and Ga\v{s}perov, Jana and Kazazi\'{c}, Sa\v{s}a and Novak, Predrag}, year = {2021}, pages = {11}, DOI = {10.3390/molecules26206316}, chapter = {26206316}, keywords = {azithromycin conjugates, macrozones, HPLC-SPE/cryo NMR, MS, structure determination}, journal = {Molecules}, doi = {10.3390/molecules26206316}, volume = {26}, number = {6316}, issn = {1420-3049}, title = {Rapid Structure Determination of Bioactive 4''- tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC/SPE/Cryo NMR and MS}, keyword = {azithromycin conjugates, macrozones, HPLC-SPE/cryo NMR, MS, structure determination}, chapternumber = {26206316} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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