Changes of neurocognitive status in patients with the first-episode psychosis after 18 months of treatment–A prospective cohort study

Bošnjak Kuharić, Dina; Makarić, Porin; Kekin, Ivana; Rossini Gajšak, Linda; Živković, Maja; Ostojić, Draženka; Silić, Ante; Bajić, Žarko; Lukačević Lovrenčić, Iva; Beezhold, Julijan; Rojnić Kuzman, Martina

doi:10.1016/j.psychres.2021.114131

Pregled bibliografske jedinice broj: 1151353

Changes of neurocognitive status in patients with the first-episode psychosis after 18 months of treatment–A prospective cohort study

Bošnjak Kuharić, Dina; Makarić, Porin; Kekin, Ivana; Rossini Gajšak, Linda; Živković, Maja; Ostojić, Draženka; Silić, Ante; Bajić, Žarko; Lukačević Lovrenčić, Iva; Beezhold, Julijan; Rojnić Kuzman, Martina

Changes of neurocognitive status in patients with the first-episode psychosis after 18 months of treatment–A prospective cohort study // Psychiatry research, 304 (2021), 114131, 8 doi:10.1016/j.psychres.2021.114131 (podatak o recenziji nije dostupan, članak, znanstveni)

CROSBI ID: 1151353 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Changes of neurocognitive status in patients with the first-episode psychosis after 18 months of treatment–A prospective cohort study

Autori
Bošnjak Kuharić, Dina ; Makarić, Porin ; Kekin, Ivana ; Rossini Gajšak, Linda ; Živković, Maja ; Ostojić, Draženka ; Silić, Ante ; Bajić, Žarko ; Lukačević Lovrenčić, Iva ; Beezhold, Julijan ; Rojnić Kuzman, Martina

Izvornik
Psychiatry research (0165-1781) 304 (2021); 114131, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
first-episode psychosis ; schizophrenia ; neurocognitive deficits ; neurocognitive symptoms ; follow-up

Sažetak
Neurocognitive symptoms exert the most influence on treatment outcomes over the course of schizophrenia, starting from the first-episode of psychosis (FEP) onwards. Our aim was to analyze the neurocognitive status of FEP compared to healthy controls (HC), and its change after 18 months of treatment. We performed a study in a sample of 159 patients with FEP and 100 HC. We followed the patients up for 18 months after initial assessment with a battery of neurocognitive tests. We observed statistically significant improvement in the majority of neurocognitive tests after 18 months, but several tests of specific neurocognitive domains (verbal memory, language functions, executive functions) did not show significant differences between the two assessments. The results for the majority of tests obtained from patients with FEP after 18 months of treatment showed significant deterioration compared with HC. Although our study showed significant improvement of baseline neurocognitive deficits in FEP with treatment, this varied across domains and overall performance remained below that of HC. Thus, while it seems that treatment of FEP may help to delay or restore neurocognitive deterioration, it is unclear whether specific areas of neurocognitive deterioration (e.g. verbal domain) would benefit from more time or specific treatment approaches.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Pravni fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb,
Fakultet hrvatskih studija, Zagreb,
Psihijatrijska bolnica "Sveti Ivan" Zagreb

Profili:

Iva Lukačević Lovrenčić (autor)