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Pregled bibliografske jedinice broj: 1151195

Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study


Ćurlin, Marija; Barbir, Rinea; Dabelić, Sanja; Ljubojević, Marija; Goessler, Walter; Micek, Vedran; Žuntar, Irena; Pavić, Mirela; Božičević, Lucija; Pavičić, Ivan; Vinković Vrček, Ivana
Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study // Particle and Fibre Toxicology, 18 (2021), 38, 16 doi:10.1186/s12989-021-00425-y (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1151195 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study

Autori
Ćurlin, Marija ; Barbir, Rinea ; Dabelić, Sanja ; Ljubojević, Marija ; Goessler, Walter ; Micek, Vedran ; Žuntar, Irena ; Pavić, Mirela ; Božičević, Lucija ; Pavičić, Ivan ; Vinković Vrček, Ivana

Izvornik
Particle and Fibre Toxicology (1743-8977) 18 (2021); 38, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
accumulation ; toxicity ; oxidative stress ; metallothionein ; Wistar rat

Sažetak
Background: Silver nanoparticles (AgNPs) are widely used in biomedicine due to their strong antimicrobial, antifungal, and antiviral activities. Concerns about their possible negative impacts on human and environmental health directed many researchers towards the assessment of the safety and toxicity of AgNPs in both in vitro and in vivo settings. A growing body of scientific information confirms that the biodistribution of AgNPs and their toxic effects vary depending on the particle size, coating, and dose as well as on the route of administration and duration of exposure. This study aimed to clarify the sex- related differences in the outcomes of oral 28 days repeated dose exposure to AgNPs. Methods: Wistar rats of both sexes were gavaged daily using low doses (0.1 and 1 mg Ag/kg b.w.) of polyvinylpyrrolidone (PVP)-coated small-sized (10 nm) AgNPs. After exposure, blood and organs of all rats were analysed through biodistribution and accumulation of Ag, whereas the state of the liver and kidneys was evaluated by the levels of reactive oxygen species (ROS) and glutathione (GSH), catalase (CAT) activity, superoxide dismutase (SOD) and glutathione peroxidase (GPx), expression of metallothionein (Mt) genes and levels of Mt proteins. Results: In all animals, changes in oxidative stress markers and blood parameters were observed indicating the toxicity of AgNPs applied orally even at low doses. Sex- related differences were noticed in all assessed parameters. While female rats eliminated AgNPs from the liver and kidneys more efficiently than males when treated with low doses, the opposite was observed for animals treated with higher doses of AgNPs. Female Wistar rats exposed to 1 mg PVP- coated AgNPs/kg b.w. accumulated two to three times more silver in the blood, liver, kidney and hearth than males, while the accumulation in most organs of digestive tract was more than ten times higher compared to males. Oxidative stress responses in the organs of males, except the liver of males treated with high doses, were less intense than in the organs of females. However, both Mt genes and Mt protein expression were significantly reduced after treatment in the liver and kidneys of males, while they remained unchanged in females. Conclusions: Observed toxicity effects of AgNPs in Wistar rats revealed sex-related differences in response to an oral 28 days repeated exposure.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2016-06-2436 - Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje (NanoFaceS) (Vinković Vrček, Ivana, HRZZ - 2016-06) ( CroRIS)
EK-H2020-814425 - Znanstveno utemeljeno upravljanje rizikom nano-tehnologije (RiskGONE) (Vinković Vrček, Ivana, EK ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi particleandfibretoxicology.biomedcentral.com

Citiraj ovu publikaciju:

Ćurlin, Marija; Barbir, Rinea; Dabelić, Sanja; Ljubojević, Marija; Goessler, Walter; Micek, Vedran; Žuntar, Irena; Pavić, Mirela; Božičević, Lucija; Pavičić, Ivan; Vinković Vrček, Ivana
Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study // Particle and Fibre Toxicology, 18 (2021), 38, 16 doi:10.1186/s12989-021-00425-y (međunarodna recenzija, članak, znanstveni)
Ćurlin, M., Barbir, R., Dabelić, S., Ljubojević, M., Goessler, W., Micek, V., Žuntar, I., Pavić, M., Božičević, L., Pavičić, I. & Vinković Vrček, I. (2021) Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study. Particle and Fibre Toxicology, 18, 38, 16 doi:10.1186/s12989-021-00425-y.
@article{article, author = {\'{C}urlin, Marija and Barbir, Rinea and Dabeli\'{c}, Sanja and Ljubojevi\'{c}, Marija and Goessler, Walter and Micek, Vedran and \v{Z}untar, Irena and Pavi\'{c}, Mirela and Bo\v{z}i\v{c}evi\'{c}, Lucija and Pavi\v{c}i\'{c}, Ivan and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2021}, pages = {16}, DOI = {10.1186/s12989-021-00425-y}, chapter = {38}, keywords = {accumulation, toxicity, oxidative stress, metallothionein, Wistar rat}, journal = {Particle and Fibre Toxicology}, doi = {10.1186/s12989-021-00425-y}, volume = {18}, issn = {1743-8977}, title = {Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study}, keyword = {accumulation, toxicity, oxidative stress, metallothionein, Wistar rat}, chapternumber = {38} }
@article{article, author = {\'{C}urlin, Marija and Barbir, Rinea and Dabeli\'{c}, Sanja and Ljubojevi\'{c}, Marija and Goessler, Walter and Micek, Vedran and \v{Z}untar, Irena and Pavi\'{c}, Mirela and Bo\v{z}i\v{c}evi\'{c}, Lucija and Pavi\v{c}i\'{c}, Ivan and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2021}, pages = {16}, DOI = {10.1186/s12989-021-00425-y}, chapter = {38}, keywords = {accumulation, toxicity, oxidative stress, metallothionein, Wistar rat}, journal = {Particle and Fibre Toxicology}, doi = {10.1186/s12989-021-00425-y}, volume = {18}, issn = {1743-8977}, title = {Sex affects the response of Wistar rats to polyvinyl pyrrolidone (PVP)-coated silver nanoparticles in an oral 28 days repeated dose toxicity study}, keyword = {accumulation, toxicity, oxidative stress, metallothionein, Wistar rat}, chapternumber = {38} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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