Naslov
Transition Metal Complexes of Dipicolylamine, Iminodiacetamide and Bis-triazole Derivatives

Autori
Jakopec, Silvio ; Pantalon Juraj, Natalija ; Brozovic, Anamaria ; Perić, Berislav ; Kirin, Srećko I., Raić- Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27HSKIKI : book of abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 177-177

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
1, 2, 3-triazole ; ferrocene ; transition metal complex

Sažetak
Ferrocene compounds have attracted significant interest as biologically active derivatives. Introduction of the ferrocene moiety in drug-like molecules improves the physicochemical properties and stability of drug candidates, while the transition metals coordinated to biologically active ligands participate in metal-specific processes which enhance drug delivery and biological activity. As part of our research of ferrocene derivatives and their transition metal complexes, we have prepared dipicolylamine, iminodiacetamide and bis-triazole derivatives connected to ferrocene through an ethylenediamine linker. The conjugates were used as ligands in the synthesis of Zn(II), Ni(II) and Cu(II) metal complexes. The stoichiometry and stereochemistry of the obtained complexes were examined by NMR and UV-Vis spectroscopy. We have obtained two crystal structures of metal complexes with bis-triazole ligands and one with an iminodiacetamide ligand. Investigation of antitumor activity is in progress.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA