Naslov
Antimicrobial activity of quaternary ammonium compounds derived from pyridinium-4-aldoxime

Autori
Šprung, Matilda ; Crnčević, Doris ; Odžak, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
quaternary ammonium compounds, pyridinium-4-aldoxime, antimicrobial activity

Sažetak
Quaternary ammonium compounds (QACs) are known for their potent antimicrobial activity, however, new data show that environmental bacteria developed resistance pointing to the importance for new QACs discovery. Our previous studies have shown that quaternary salts of heterocyclic derivatives, 3- substituted quinuclidine and benzylimidazole, have good antimicrobial activity acting on the bacterial membrane and binding to DNA. Led by these findings, we used pyridinium-4-aldoxime as biologically active heterocyclic precursor known for its antidote application. For reactions of quaternization we used different aryl/alkyl bromides obtaining corresponding QACs in very good yields. New compounds were tested against a panel of pathogenic Gram-positive and Gram-negative bacteria including standard benzyldodecyldimetylammonium bromide (BAB). Preliminary data show that quaternization of pyridinium-4-aldoxime significantly affect its antimicrobial activity irrespective of the quaternization agent. Also, all QACs obtained with alkyl reagents show lower MIC values for both Gram negative and positive bacteria, however observed values (312 µg/mL) were 100-fold higher than for BAB (2 µg/mL). Regardless, refinement of these structures, using other reagent(s) for quaternization might lead to better biological activities of pyridinium-4-aldoxime.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA