Naslov
(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

Autori
Sabol, Maja ; Calleja-Agius, Jean ; Di Fiore, Riccardo ; Suleiman, Sherif ; Ozcan, Sureyya ; Ward, Mark P. ; Ozretić, Petar

Izvornik
Cancers (2072-6694) 13 (2021); 5040, 36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
rare ovarian cancers ; long non-coding RNAs ; lncRNAs ; competing endogenous RNA ; ceRNA ; ovarian cancer biomarkers ; lncRNA-based therapy

Sažetak
Rare ovarian cancers (ROCs) are OCs with an annual incidence of fewer than 6 cases per 100, 000 women. They affect women of all ages, but due to their low incidence and the potential clinical inexperience in management, there can be a delay in diagnosis, leading to a poor prognosis. The underlying causes for these tumors are varied, but generally, the tumors arise due to alterations in gene/protein expression in cellular processes that regulate normal proliferation and its checkpoints. Dysregulation of the cellular processes that lead to cancer includes gene mutations, epimutations, non-coding RNA (ncRNA) regulation, posttranscriptional and posttranslational modifications. Long non-coding RNA (lncRNA) are defined as transcribed RNA molecules, more than 200 nucleotides in length which are not translated into proteins. They regulate gene expres-sion through several mechanisms and therefore add another level of complexity to the regula-tory mechanisms affecting tumor development. Since few studies have been performed on ROCs, in this review we summarize the mechanisms of action of lncRNA in OC, with an empha-sis on ROCs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA