Naslov
Dementia linked to unregulated hypertension and vitamin D deficiency

Autori
Đermanović Dobrota, Vesna ; Prkačin, Ingrid ; Jug, Juraj ; Dobrota, Savko ; Lukinović Škudar, Vesna ; Filipović Grčić, Luka ; Butković Soldo, Silva

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Mind & brain : abstract book 2021 / - Pula, 2021, 82-82

Skup
60th International neuropsychiatric congress Mind & brain

Mjesto i datum
Online, 27.05.2021. - 30.05.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
arterial hypertension ; dementia ; vitamin D

Sažetak
Introduction/Objectives: Over 40 million people worldwide have dementia. The number of people with dementia is expected to double every 20 years due to rapid global demographic changes, making dementia one of the largest socioeconomic and health challenges worldwide. Blood pressure (BP)― high, low, and fluctuations ― is the most powerful, treatable risk factor for dementia. Increased fluctuations in BP induce shear stress on the vessel wall that can cause microvascular damage by promoting endothelial injury and disturbing vascular smooth muscle functioning. Previous research has shown that a dysfunctional blood-brain barrier could promote amyloid beta accumulation. BP variability has been identified as a predictor of cardiovascular outcomes, but its potential relationship with incident dementia and vitamin D and hypertensive crisis has not been studied. Participants, Materials/Methods: During routinely examination for hypertension in Clinical Hospital Merkur 120 patients were examined. Blood pressure was monitored by 24 hour holter. Homocysteine, glucose, 25(OH) vitamin D, total cholesterol and creatinine levels were observed from the serum. Total number of hypertensive years was also calculated and patient’s past history taken. All parametric data was processed by student t-test and ANOVA. To determine correlation between nonparametric variables Spearman’s test was used. All data was analyzed by Statistica v. 10.0. The Mini–Mental State Exam (MMSE) was used to assess cognition. Results: Patients with dementia observed by MMSE were significantly older (73.36 vs. 63.32 years, p < 0.0001), had higher values of homocysteine (25.23 vs 18.22 mcmol/L, p < 0.0001), systolic blood pressure measured by 24- hour holter (146.21 vs. 139.21 mmHg, p = 0.02) and lower values of GFR calculated by CKD-EPI formula (58.56 vs. 67.68 mL/min, p = 0.03). Even though statistically insignificant, higher BMI was noticed in patients with dementia (32.74 vs. 30.79 kg/m2, p = 0.07). Vitamin D deficiency was also noticed to be more common in obese (32.38 vs. 29.92 kg/m2, p = 0.06) and older patients (70.18 vs. 63.87 years, p = 0.03) causing big difference in MMSE results in the end (22.67 vs. 26.54, p = 0.0000, CI 2.65- 5.07). Results are compared on figure 1. Vitamin D deficiency was more often seen in women (OR 2.55, p < 0.05, CI 1.02-6.36) just as the results of MMSE are lower (22.97 vs 24.16, p = 0.036, CI = 0.07-2.31). Comparison of patients with hypertensive crisis and without it showed statistically lower MMSE result in positive patients (22.78 vs 25.55, p < 0.001, CI = 1.56 – 3.97). Higher BMI (32.69 vs. 29.28 kg/m2, p = 0.005) and total cholesterol levels are noticed (5.85 vs. 5.36, p < 0.05). Poorer blood pressure regulation was found in patients with vitamin deficiency (r = 0.3 p<0.01). Conclusions: In future research, the investigators intend to identify the mechanisms by which variability in BP changes and vitamin D deficiency increase dementia risk.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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